@anshu Use of the decision-support risk calculator for thromboembolism in the IMPROVE-DD VTE trial significantly boosted use of appropriate inpatient thromboprophylaxis starting at hospital admission by a relative 52%, and significantly increased outpatient thromboprophylaxis prescribed at discharge by a relative 93% in the study's two primary endpoints, Spyropoulos reported at the American Heart Association scientific sessions.

@shrutishreya More specifically, the deep TTR reductions observed in patients with ATTR amyloidosis in this study provide a real possibility of genuine clinical improvement in a condition that has hitherto been ultimately progressive and invariably fatal

@prem Patients in the intervention group who recorded a urate level above 0.30 mmol/L (5 mg/dL) via the app during the study were prompted to do a self-test every 2 weeks and given daily reminders in the app. Their urate levels were transmitted securely to the study team who then advised on dose escalation or treatment change. Those in the usual-care group also used the app but it only prompted them to record gout flares, keep quality of life diaries, or message the researchers.

@dharsumi Although VR improved symptoms of indigestion, researchers still do not know exactly how it works. There are some theories: Immersion in a different world distracts people from belly pain. VR also could change the signals sent between the brain and the gut, thereby easing discomfort and pain

@pratiksha The researchers call it "human-in-the-loop optimization." The boots learn not only a person’s stride length and speed, but also their metabolic rate and energy use. They also measure ankle motion and force. The results: A person can walk 9% faster and spend 17% less energy when wearing them. That’s roughly the boost you’d expect from taking off a 30-pound backpack.

@sasical In a feasibility study of more than 2000 patients seen at diabetes clinics, clinicians entered patient data into the app, which takes about 20 seconds. Based on the data, the app classified CV risk in the cohort as very high (72.2% of patients), high (9.9%), or moderate (0.8%). However, 18.2% of patients did not fit any of the risk categories and were deemed to have moderate to high CV risk.

@piyush-ashish In a prospective trial, 40 patients between the ages of 36 and 75 years were enrolled with visible signs of facial aging who were seeking skin tightening treatments at one of three centers in the United States. They underwent three biweekly treatments with the Evoke device to the lower face and submental area where a target temperature of 42°-43° C was maintained for 41 minutes, or about 20 minutes for each site.

@mainak Retrospectively, with the software, we saw how the image was clarified and no pathological image was present. This patient could have avoided the angiography and could have avoided a hospital stay, plus the risk with intervention, such as bleeding, stroke, increased radiation on the table, and potential damage from the instruments

@kirti The smartwatch recordings were reviewed by a blinded electrophysiologist who interpreted each tracing and assigned a diagnosis of "AF," "absence of AF," or "diagnosis unclear." To assess interobserver agreement, a second blinded electrophysiologist interpreted 100 randomly selected tracings.

@yanara The researchers found that with the addition of CADe, the adenomas per colonoscopy (APC) rate increased from 0.51 to 0.70, which was statistically significant. The adenoma detection rate (ADR) increased from 30% to 37%, and the adenoma miss rate (AMR) decreased from 36% to 19%. The study is unique in its testing of CADe in daily clinical care, and the results support use in this setting.

@gerger Capsule endoscopy and deep enteroscopy are long overdue for this set of quality indicators. There is much variability across the country as to when the procedures are implemented and how they are performed. The relative novelty of these procedures explains the delay in developing quality indicators, said Semrad, a professor of medicine and director of adult clinical nutrition and small bowel disease at University of Chicago Medicine, Chicago, Illinois. She noted that the main barrier to creating quality indicators was the lack of rigorous randomized controlled clinical trials to guide practice and therapy.

@pritam Approximately 6.5 million Americans aged 65 years or older have Alzheimer's disease or another form of dementia, according to the researchers. The median survival time from age at diagnosis varies widely, ranging from 3.3 to 11.7 years, they add. The ability to better predict which patients are more likely to survive longer with dementia could significantly help with financial planning, clinical choices, the use of long-term care, and other types of decisions for this population.

@vinit The thermal imaging allowed for noninvasive yet precise temperature measurement at three predefined points on the dominant hand of the user (mid-palm, tip of third finger, tip of thumb) at four distinct time points (before applying sanitizer gel, immediately after hands felt dry, 1 minute later, and 2 minutes later). Researchers also explored the relationship between the amount of gel used and hand size to see if they were related to the temperature drop.

@mithu When a potential polyp is detected, the system calls attention to the polyp on the procedure monitor by drawing a blue bounding box around it, and it tracks the polyp as it moves on the screen. If a medical tool enters the frame, the bounding box automatically disappears to avoid obstructing the endoscopist's view during polyp removal.

@michell Telemedicine bridged the gap between rural doctors and patients in several ways. It enabled physicians to discuss cases with neurologists in and out of Kenya. More than 100 patients were diagnosed with a movement disorder and enrolled in care and follow-up during this 2-year time. Patients averaged about 62 years of age and more than 60% were male. Parkinson's disease was the most common diagnosed condition (38.9%) followed by drug-induced movement disorders (30.6%), dystonia (11.1%), and functional movement disorders (11.1%).

@panama The algorithm converts an image into a set of numbers that is unique to that tumor. The large number of tumors that we analyzed allowed us to learn which features were most predictive of tumor behavior. We can now apply what we have learned to new colon cancers to predict how the tumor will behave

@neel Currently, the gold standard in PD is to look at motion-based symptoms, whereas the evidence points to a very strong connection" between PD and nocturnal breathing

@udipta Perspiration has intrigued scientists for centuries. As far back as the second century AD, Galen – a prominent Greek doctor in the Roman Empire – explored whether people could sweat body fat from their pores or detox their blood by sweating. While fat tissue won't seep out of your pores, other substances will. Sweat is 99% water but contains small amounts of sodium, chloride, lactate, glucose, cortisol, ammonia, urea, ethanol, and small proteins. Sweat may also hold trace amounts of chemicals and toxins, such as heavy metals and bisphenol A (BPA), but only if they were present in the blood. (Everts once reported a rare case when a nurse's sweat turned red from eating enormous amounts of chips with red dye). There is a strong link between the level of alcohol in your blood and the amount found in your sweat.
Beginning in 2003, what's known as SCRAM CAMs (which stands for SCRAM Continuous Alcohol Monitoring) were created to help police and courts with continuous alcohol monitoring of high-risk DUI offenders and domestic violence cases.
It's like having a breathalyzer attached to your ankle, always looking for alcohol in your sweat.

@patralekha Over the past decade, AI speech analysis has been shown to help detect Parkinson's disease, posttraumatic stress disorder, dementia, and heart disease. Research has been so promising that the National Institutes of Health just launched a new initiative to develop AI to use voice to diagnose a wide array of conditions. These range from such respiratory maladies as pneumonia and COPD to laryngeal cancer and even stroke, ALS, and psychiatric disorders like depression and schizophrenia. Software can detect nuances that the human ear can't. At least half a dozen studies have taken this approach to COVID detection. In the most recent advancement, researchers from Maastricht University in the Netherlands are reporting their AI model was accurate 89% of the time, compared with an average of 56% for various lateral flow tests. The voice test also was more accurate at detecting infection in people not showing symptoms.

@sucheta It elevates endogenous opioids, so it's actually operating through some of the same pathways as opioids. But because it's all endogenous, it's very precise and doesn't have some of the negative side effects of prescription opioids such as addiction or euphoria; this is purely for pain control.