@nirdesh There was no difference in the primary endpoint components of operative mortality (2% methylprednisolone group vs 2.8% placebo), a composite of mortality and major complications (17.2% vs 20.3%), and prolonged mechanical ventilation (6.8% vs 8.5%).

Babies who received methylprednisolone were also more likely to have high blood glucose levels, a known stress response to surgery, with 19% requiring postoperative insulin vs 6.7% with placebo (P < .001), according to results published November 6 in the New England Journal of Medicine.

@quintin However, one area did see a significant difference when they looked at answers to the Ages and Stages Questionnaire, 3rd edition (ASQ-3): Scores were lower in communication skills.

Compared with the prepandemic babies, the pandemic group of babies was more likely to have communication impairment (odds were 1.7 times higher).

Additionally, mothers' SARS-CoV-2 infection was not associated with significant differences in any neurodevelopment sector in offspring, with one exception: Odds were 3.5 times higher for fine motor impairment in the pandemic baby group.

The babies in this study were either exposed in the womb to the SARS-CoV-2 infection or screened during the pandemic regardless of whether they were exposed to the virus.

@moucheta A similar increase can be seen for hospitalizations with confirmed COVID. The rate for children aged 0-17 years fell from 0.44 admissions per 100,000 population at the end of August to 0.16 per 100,000 on Oct. 23. Hospitalizations have since ticked up to 0.17 per 100,000, according to the Centers for Disease Control and Prevention.

Emergency department visits with diagnosed COVID among children aged 16-17 years, as a percentage of all ED visits, rose from 0.6% on Oct. 21 to 0.8% on Oct. 26. ED visits for 12- to 15-year-olds rose from 0.6% to 0.7% at about the same time, with both increases coming after declines that started in late August. No such increase has occurred yet among children aged 0-11 years, the CDC reported on its COVID Data Tracker.

@onde The shortage impacts three of the four largest amoxicillin manufacturers worldwide, according to the Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota. The FDA listed the reason for the shortage as “demand increase for drug,” except in the case of manufacturer Sandoz, for which the reason listed read “information pending.”

@jack-jason Women who received usual care following cesarean section were more likely to have uterine contractions at the umbilical level compared with the skin-to-skin contact group (70% vs. 3%; P ≤ .0001), while the skin-to-skin group was more likely to have uterine contractions at the infraumbilical level (92.5% vs. 22.5%; P ≤ .0001). There was a statistically significant decrease in predischarge hemoglobin in the control group compared with the skin-to-skin group (10.522 vs. 11.075 g/dL; P ≤ .017); the level of hemoglobin reduction favored the skin-to-skin group (1.01 vs. 2.265 g/dL; P ≤ .0001). Women in the skin-to-skin group were more likely to report mild pain on a 10-point visual analog scale (VAS) after being transferred to the recovery room (1.48 vs. 6.23 points; P ≤ .0001) and being transferred to a maternity room or room in the postpartum unit (0.60 vs. 5.23 points; P ≤ .0001). Breastfeeding at birth was significantly higher among patients with immediate skin-to-skin contact compared with the control group (92.5% vs. 32.5%; P ≤ .0001), and continued at 1 month after birth (92.5% vs. 12.5%; P ≤ .0001). Newborns of mothers in the skin-to-skin group were significantly less likely to cry compared with newborns in the control group (90% vs. 55%; P ≤ .001).

@tausha In 2015, when the American Thyroid Association [ATA] created their pediatric guidelines [on RAI therapy in DTC], they were taking a leap of faith that these [pediatric DTC] patients would be able to achieve remission without RAI

@debtanu At 2 years, 23% of the emollient group vs 25% of the control group developed eczema (adjusted relative risk, 0.95), and the parent-reported clinical skin infection rate was statistically increased (incidence rate ratio, 1.55). Despite these results, follow-up of BEEP was extended to 5 years to determine if there was a delayed benefit of emollients, both in AD prevention, but also with other related disorders

@fikham The important new things that attendees may want to take away from this for their practice are improved recognition and diagnostic workup for acute viral myocarditis, making sure cardiology follow-up occurs after an admission for the condition, enhanced evaluation of the child before they return to competitive sports, and the availability of written or verbal education for patients relating to COVID vaccine–associated myocarditis

@niteeesha Using these measures, we've been able to demonstrate that even at slightly lower levels of blood pressure than might be expected to cause damage, there actually are some changes occurring in adolescence. The take-home message is that damage may be occurring to important organs like the heart (increased LV mass) at BP levels lower than the established definition of hypertension in youth (the age-, sex- and height-specific 99th percentile of BP in healthy kids)

@ence Food insecurity was assessed using the US Department of Agriculture (USDA) food security survey module. Blood pressure was measured three times and averaged. High blood pressure was defined as systolic or diastolic blood pressure in the 90th percentile for children younger than 13 and a measurement of 120/80 mm Hg or higher for children 13 years and older, a reported diagnosis of hypertension, or reported current use of an antihypertensive medication.

@yanara Children who have experienced trauma can have issues with behavior, it can impact their school, and they have difficulties sleeping. The version for teenagers contained a sound machine, aromatherapy spray, and a sleep mask. The kits for younger children contained matching stuffed toys to share with someone they felt connected to, and a rechargeable night-light. All kits included written materials about sleep hygiene, a journal, and directions for downloading a free age-appropriate relaxation app for belly breathing or a PTSD Coach app from the US Department of Veterans Affairs to manage symptoms of trauma.

@dheya The implementation of CHART as a first-step screening tool in general practice could promote timely treatment control and, in turn, improve quality of life for patients and reduce the clinical and economic burden of asthma

@niraj Most of the deaths (61%) occurred in the child's home, and in even more cases (71%) the child was being supervised when the poisoning occurred, most often by a parent (58.5%). The others supervising children were usually a grandparent (11%) or another relative (5.5%). The child was in view of the supervising individual in 28.5% of the deaths. A child protective services case was opened in 13% of the cases.

@lushan Pertussis is a highly contagious respiratory tract infection caused by the bacterium Bordetella pertussis. Most cases that result in hospitalizations and death are among infants within 2 months of birth. The FDA said its decision was based on data from observational studies, which included 108 cases of pertussis in infants younger than 2 months old. According to data evaluated by the agency, the vaccine was 78% effective in preventing whooping cough.

@yakshi Thirty children in the study received eyedrops containing the antibiotic moxifloxacin. They got better in 3.8 days on average. Twenty-seven children received placebo eyedrops, and they recovered in 4 days on average. The difference between the groups was not statistically significant, according to the researchers. Another group of 31 children received no intervention. Their symptoms resolved in 5.7 days on average. The difference between the moxifloxacin group and the no-treatment group (1.9 days) was statistically significant (P = .04), whereas the difference between the placebo group and the no-treatment group (1.7 days) was not (P = .10), the researchers found.

@jitendra Women with epilepsy are advised to take high doses of folic acid before and during pregnancy owing to the risk for congenital malformations associated with ASM. Whether high-dose folic acid is associated with increases in the risk for childhood cancer is unknown. To investigate, the researchers analyzed registry data from Denmark, Norway, and Sweden for 3.3 million children followed to a median age of 7.3 years. Among the 27,784 children born to mothers with epilepsy, 5934 (21.4%) were exposed to high-dose folic acid (mean dose, 4.3 mg), with 18 exposed cancer cases compared with 29 unexposed cancer — yielding an adjusted hazard ratio (aHR) of 2.7 (95% CI, 1.2 - 6.3).

@anindita The investigators of the BASELINE study found that skin barrier function, as measured by trans-epidermal water loss, increased from birth to 8 weeks but then became stable at 6 months. These observations suggest that the period during early infancy could be a critical window in which to protect the skin barrier of infants at risk for AD

@debraj In one study, amounts of melatonin ranged from less than one half to more than four times the amounts stated on the labels. The greatest variability in melatonin content was in chewable tablets, which are most likely to be used for children.

@chapal Fathers today are more involved with their children than ever before, and they want to know from the pediatrician how their child is developing. Fathers want to be included and made welcome in the doctor's office. Especially with more women entering the workforce, more fathers are stepping in to provide care and they want to know from the doctor what is best for their children

@samiran Generally, chiropractors are licensed health professionals who use stretching, pressure, and joint manipulation on the spine to treat patients. Although chiropractic care is typically seen as an "alternative therapy," some data in adults suggest that chiropractic treatments can help some conditions, such as low back pain