@abhila Chronic neuroinflammation secondary to either intrinsic or systemic stimuli is thought to play a key role in dementia development, especially Alzheimer's dementia (AD). Research showing a role of tumor necrosis factor–alpha (TNF-alpha) in the development of dementia has piqued interest in a potential protective effect of TNF inhibitors. "TNF-alpha is thought to have an important role in different stages of the pathophysiology and disease progression of Alzheimer's disease," study first author Sebastian E. Sattui, MD, assistant professor of medicine at the University of Pittsburgh and director of the University of Pittsburgh Vasculitis Center, said in an interview. "Animal models have shown that TNF inhibition reduces microgliosis, neuronal loss, and tau phosphorylation. Cognitive improvement has been seen in two trials with Alzheimer's disease patients, but were not in rheumatoid arthritis patients."

@richardson Gout was associated with a 68% increased risk of heart failure (HF) hospitalization, 25% increased risk of HF-related death, and a 22% increased risk of major adverse cardiovascular events (MACE), said Johnson, of the division of rheumatology at the University of Nebraska, Omaha.
Poorly controlled serum urate was associated with a higher risk of cardiovascular events, regardless of the use of urate-lowering therapy (ULT). He said more research is needed to see if there is a causal link between gout, hyperuricemia – or its treatment – and CVD risk.

@esha Primary care physicians, surgeons, and researchers are trying to identify risk factors, medication regimens, and nondrug approaches to avoid these complications. Primary care clinicians who make their patients' bone health a priority early on ― years before surgery, ideally ― may help patients enjoy the benefits of new joints long term.

@kathil However, the results are quite comparable and very much in line with what's been seen with standard palliative radiotherapy rates of pain flare pain response, [and] retreatment rates were very similar to previously reported data using the same dose of 8 Gy

@niraj Women also scored higher than men on measures of disability and work impairment, with mean HAQ-DI scores of 0.56 vs. 0.41 and mean WPAI scores of 27.9% vs. 24.6%, respectively (P < .01). Disease burden was significantly higher in women vs. men based on PsAID12 scores (2.66 vs. 2.27, respectively) and women reported significantly higher levels of fatigue and pain (P < .01 for all). More men than women reported working full-time (68.6% vs. 49.4%) but no gender differences emerged for work time missed because of PsA, the researchers noted.

@sasical The researchers randomly assigned 200 patients undergoing outpatient arthroscopic shoulder or knee surgery to receive an opioid-sparing protocol or standard care, which consisted of an opioid analgesic. The opioid-sparing protocol included:
Naproxen
Acetaminophen (paracetamol)
Pantoprazole
A limited rescue prescription of hydromorphone in case of breakthrough pain
Patient education, including information on pharmacologic and nonpharmacologic pain management strategies

@erya During discography, contrast medium is injected into the disk and the patient's response to the injection is noted; provocation of pain that is similar to the patient's existing back or neck pain suggests that the disk might the source of the pain. Computed tomography (CT) is usually performed after discography to assess anatomical changes in the disk and to demonstrate intradiscal clefts and radial tears.

@onea Gout can cause flare-ups that vary in frequency and severity; but sometimes when people aren't experiencing them, they're less likely to stay on top of their medications. That's why lifestyle interventions are seen as particularly relevant to a disease like gout. Vitamin C, for example, has few side effects, and for those with higher levels of uric acid in the blood, it could reduce the likelihood of getting the condition. A recent study published in The American Journal of Clinical Nutrition found that people who were given 500 milligrams of vitamin C versus a placebo had a 12% reduced risk of getting gout. The study of over 14,000 male doctors showed that men who weren't overweight had the most significant reduction in the risk of getting the condition.

@susan_lyan Unless your Hercules when you have knee surgery it hurts and it hurts a lot. Whether you have a scope ( which is in my opinion the least painful ) or a total knee pain becomes part of your life. It seems myself included when I deal with pain every day it gets old fast what stinks is the pain lasts months and sometimes as in my case years. ( I am a tad different ). The biggest thing to improve recovery time is exercise but do not do it to the point you are in agony. Something else to watch out for is infection. Signs of infection skin are very warm almost hot, swelling, redness, fever., and severe pain. It makes no sense but you can have some of these symptoms but no infection. I am 2 yrs post-op from a TKR and there are days for no reason I am miserable when the weather changes if I walk too far, or work in the yard too long. You will get better just be patient.

@susan_lyan The idea I believe is to apply pressure gently until it is a good stretch - you should feel it, but not be painful - and then keep the pressure there for a moment - remove, relax and repeat. Not sharp presses, that would hurt. It's about getting the stretch and holding it so a gradual pressure means you can get to wear you feel the work is happening but it is not hurting you.
Good luck.

@margie hi, I think that trip sounds terrible to do this soon after surgery. you will be very uncomfortable. try to make other arrangements. see if a friend or relative can stay with you while friends away.
best wishes!

@ann Hi ann
omg, so im not the only one, post op 4 weeks yesterday for a tkr.
Not one good night's sleep in all that time like you have tried everything possible.
And yes I've got a memory foam pillow .its one I bought from Amazon between my legs has helped.

@bidhan Sex is the biological characteristic of being male or female. It relates to disease inheritance patterns, pain processing mechanisms, and immune dysregulation in the context of inflammatory arthritis

@bratati Fibromyalgia is complex and largely unexplained, but abnormality in pain modulation is one of its hallmarks. Understanding how this modulation plays out in the central nervous system could give some insights into the cause of the condition. To examine this phenomenon, the researchers scanned the brains of 12 women with fibromyalgia by using functional MRI. The women's mean age was 39.5 years, and their mean Fibromyalgia Impact Questionnaire score was 52.9. The scale runs from 0 to 100 in order of increasing severity.

@timsim Knock knee can be caused by an underlying congenital or developmental disease or arise after an infection or a traumatic knee injury. Treatment for knock knees depends on the cause and severity of the condition. Treatments other than surgery include medication and regular exercise. For most people with genu valgum, exercise can help realign and stabilize their knees. Your doctor or physical therapist can evaluate your gait and suggest exercises designed to strengthen your leg, hip, and thigh muscles. Specific stretches may also be useful in relieving symptoms. You should consult other doctors as well and know what caused him knock knees in the first place. If knock knee is caused by an underlying disease or infection, that condition will be addressed before any orthopedic correction begins. Thanks.

@haritt Hey, The exact cause of childhood arthritis is unknown. In childhood arthritis, the immune system may not work right which causes inflammation in the joints and other body systems. In childhood arthritis, the immune system may not work right which causes inflammation in the joints and other body systems but the exact cause of childhood arthritis is unknown. Childhood arthritis can affect children of all ages but it is more in the kids under 16 years of age. Usually, arthritis is common among people between the ages of 40 and 60. Childhood arthritis can also be hereditary.

@nujh Lifting elevated levels of weights with a tight grip, over and over, creates an intense kind of repetitive stress on the hand and wrist area. Carpal tunnel syndrome is caused by the compression of the median nerve at the base of the hand. Carpal tunnel syndrome is an orthopaedic condition and should be diagnosed by an orthopedic surgeon or a hand specialist. The doctor will conduct a medical examination and may also order some diagnostic or imaging tests to assess the condition of the hand. The surgeon may also ask you questions or perform a physical diagnosis to assess the sensations and functioning of the wrist and hand, ask about your medical history, and analyze your daily lifestyle and symptoms. Daily exercise helps to stimulate flexible arteries and veins which are key to healthy blood circulation in the extremities of the body, like the hand and wrist areas. Take precautions while weight lifting exercises to prevent carpal tunnel syndrome. Thanks!

@reyn yes, as long as the condition is diagnosed early and symptoms aren't severe. Also, Try wearing a wrist brace at night
Try wrist, and hand stretching exercises
Increase physical activity and exercise
Modify your hand activities
Talk to your doctor about whenever needed
Thanks

@vein Hello, osteoarthritis is common in females. The following things might help.
Tips for Managing Arthritis in Older Adults

Listen and be Empathetic. Keep a Journal of Symptoms. Communicate with Healthcare Providers. Encourage Movement and Regular Exercise. Assist with Medication and Treatment Management. Assist with a Nutritious Diet. Encourage Weight Loss if Needed. Hire Professional Help Give her emotional support whenever needed.
Thanks

@bell Hello, yes it is normal and many people experience it. It is sometimes known as handlebar palsy and it occurs when there is compression of the ulnar nerve which runs to your little finger and ring finger. The wrist is a complex structure including multiple joints, ligaments, and nerves. Damage to any of these can lead to pain in the wrist. Overuse, overexertion, impact injuries, and several health conditions can all cause damage in the wrist, and ultimately pain. If it doesn’t get better please contact a doctor. Thank You.