@fritzi Hello, genetics and your family history play a role. It’s possible that up to 70% of autoimmune diseases may actually be caused by environmental factors, such as diet, exercise, and lifestyle play a vital role. In most cases, your genes don’t cause AID on their own fueled by a combination of genetics, immune system changes, and your environment. Thus, autoimmune disorders run in families, and susceptibility genes have been identified. There must be an environmental trigger to set off the autoimmune response