@parnika Hello, Breast tenderness of acute onset is usually either due to impending menstrual period, use of birth control pills such as Microgynon, or some inflammatory process. The achiness you've been experiencing could be a part of this new premenstrual syndrome for you but possibly caused by two years of Microgynon. Again, if all this doesn't revolve around the time of your period or if your period fails to arrive, which also can happen with Microgynon)then by all means have yourself seen. Please follow up with your doctor.