What are the CDC guidelines for the treatment of latent tuberculosis infection (LTBI)?
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What are the CDC guidelines for the treatment of latent tuberculosis infection (LTBI)?
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@glenn Patients with a clinically significant result on tuberculin skin testing or a positive interferon-gamma release assay (IGRA) result should receive a course of therapy for latent TB, once active infection and disease are ruled out. Recommended regimens for latent TB published by the US Centers for Disease Control and Prevention (CDC) are as follows [8, 12] :
Isoniazid 300 mg - Daily for 9 months
Isoniazid 900 mg - Twice weekly for 9 months (administered as DOT)
Isoniazid 300 mg - Daily for 6 months (should not be used in patients with fibrotic lesions on chest radiography, patients with HIV infection, or children)
Isoniazid 900 mg - Twice weekly for 6 months (administered as DOT; should not be used in patients with fibrotic lesions on chest radiography, patients with HIV infection, or children)
Rifampin 600 mg - Daily for 4 months
Rifapentine 750-900 mg (based on weight) plus isoniazid 900 mg - Once-weekly for 12 weeks (self-administered or as DOT)
No longer recommended - Rifampin plus pyrazinamide daily for 2 months (increased liver toxicity)