Menopause before age 40 years is associated with elevated risk of heart failure and atrial fibrillation, according to a study published in European Heart Journa, a journal from the European Society of Cardiology (ESC). The study of more than 1.4 million women revealed that the younger the age at menopause, the higher the risk of heart failure and atrial fibrillation.

Many women with symptoms of menopause are turning to cannabis for help, researchers have found, despite a lack of evidence that the drug works for these issues. In a survey of perimenopausal and menopausal women who said they've used cannabis, nearly 80% said they use medical marijuana to alleviate symptoms like sleep disturbances, hot flashes, and mood swings.

The US Food and Drug Administration (FDA) is trying to improve how oncology drugs arrive in the clinic by making changes to the accelerated approval process, making a move towards optimal rather than maximally tolerated doses in drug development, and also making clinical trials more accessible. All these points were discussed by Richard Pazdur, MD, head of the FDA's Oncology Center of Excellence at a special session during the recent annual meeting of the American Society for Clinical Oncology (ASCO).

Antibiotics are among the most commonly prescribed medications in both outpatient and hospital settings. Global efforts at curbing antibiotic-resistant strains have prompted clinicians to pursue better stewardship, whereby they limit their prescribing of such medications to those who truly need them. Yet there's another possible means of addressing antibiotic resistance — using dietary interventions to reduce the gastrointestinal (GI) complaints that so often accompany the use of antibiotics: vomiting, nausea, diarrhea, bloating/indigestion, abdominal pain, and loss of appetite. Far from being a mere nuisance, these complications can have major ramifications.

@tasmeen To reduce distraction or overstimulation, evaluations of the patient are best performed in a safe quiet area, away from the prying eyes and ears of other staff and patients. Care providers should be included in the assessment process because they can be a calming influence on the patient and they can provide valuable information. Taking a biopsychosocial approach to problem solving should lead to interventions that address biological, psychological, and social factors that caused the crisis situation. While resolving every aspect of the crisis is not necessary, identifying and addressing the main concerns of the caregivers is important. Once the immediate crisis is resolved, the remaining problems can be referred to community or state agencies.

@torsha Antibiotics usually are the first line treatment for urinary tract infections. Which drugs are prescribed and for how long depend on your health condition and the type of bacteria found in your urine. Drugs commonly recommended for simple UTIs include:
Trimethoprim/sulfamethoxazole (Bactrim, Septra, others)
Fosfomycin (Monurol)
Nitrofurantoin (Macrodantin, Macrobid)
Cephalexin (Keflex)
Ceftriaxone
The group of antibiotic medicines known as fluoroquinolones — such as ciprofloxacin (Cipro), levofloxacin and others — isn't commonly recommended for simple UTIs, as the risks of these medicines generally outweigh the benefits for treating uncomplicated UTIs. In some cases, such as a complicated UTI or kidney infection, your doctor might prescribe a fluoroquinolone medicine if there are no other treatment options.

@ayush Phenolic Antioxidant compounds are what give pistachios their reputation as free radical fighters and are a skincare product mainstay. In addition, pistachios contain catechins, plant-based flavanols, which are another type of antioxidant that helps protect the body from damage done to skin cells by free radicals. Free radicals are unstable atoms that are missing an electron, and often pair with other electrons. They are known to cause damage to the DNA within cells. When the damage is done to skin cells, there can be an impact on the cell’s membrane and its mitochondria, which causes the appearance of premature aging. This “premature aging” is often characterized by sagging skin, hyperpigmentation, or age spots, loss of elasticity, fine lines and wrinkles, and other attributes that make a person look older than their actual chronological age. This damage to the cell’s genetic materials includes affecting their growth, function, and ability to repair. The body has its own antioxidant defense against free radicals, but if the cells are overwhelmed by an abundance of free radicals, the body can’t keep up. That’s where topical or antioxidants from food come into play. Pistachio oil is a potent antioxidant. It helps the body counteract free radicals, helping to prevent key molecules in the skin cells from becoming damaged.

Hello, a 64-year-old lady who presented with acute-onset abdominal pain, nausea, vomiting and shortness of breath. Blood gas results (pH 7.10, bicarbonate 2.9 mmol/L) confirmed metabolic acidosis, and the presence of raised ketones (serum ketones 5.5 mmol/L) allowed a diagnosis of ketoacidosis. Initially, doctors caring for the patient entertained the possibility that the lady was suffering diabetic ketoacidosis, but her normal blood glucose concentration (5.8 mmol/L) and preserved mental status suggested this was unlikely. A diagnosis of alcoholic ketoacidosis was finally made when she reported drinking 1-2 bottles of wine per day for the past 30 years, and admitted to a period of binge drinking immediately prior to the onset of symptoms and subsequent admission to hospital.

A 31-year-old male student in his fourth year of law school had a long history of experimental drug use including alcohol (his first drug), marijuana and LSD; but at no time had he abused a psychoactive drug. Approximately two years ago he was introduced to cocaine in a social setting by a group of friends and fellow law students. He became a regular recreational user of cocaine and in a social setting during an evening would chop up and snort between 10 and 20 lines of cocaine in the usual fashion. (Often, as with this case, cocaine is used in a recreational setting along with alcohol and marijuana.) With this law student, the pattern of recreational cocaine use continued for some time, but moved to a more daily pattern when he found that the inhalation of cocaine stimulated his performance and ability to study at night, something he found desirable because he had begun to prepare for the bar examinations. How to get rid of addiction?

Hello, a 40-year old woman presented with asymptomatic idiopathic facial lipoatrophy. The patient was otherwise healthy, taking no medications with no trauma or surgery in the region affected. Investigations, including a full autoimmune workup, were unremarkable. The facial lipoatrophy was considerably disfiguring and was assessed as a Grade 4 on the facial lipoatrophy scale. The patient was treated over the course of 2 years with two autologous fat transfers. How to treat this?