@tishta Scientists identified palbociclib (used to treat breast cancer) and cardiac glycosides (used to treat heart failure and heart rhythm disorders), which might be repurposed to treat type 2 diabetes.

The number of people living with type 1 diabetes worldwide is expected to double by 2040, with most new cases among adults living in low- and middle-income countries, new modeling data suggest. The forecast, developed from available data collected in the newly established open-source Type 1 Diabetes Index, provides estimates for type 1 diabetes prevalence, incidence, associated mortality, and life expectancy for 201 countries for 2021. The model also projects estimates for prevalent cases in 2040. It is the first type 1 diabetes dataset to account for the lack of prevalence due to premature mortality, particularly in low- and middle-income countries.

The assumption that gout is mainly caused by diet is wrong, according to a meta-analysis of diet and genetic variants in over 16,000 subjects. The analysis, which was published online today in BMJ, suggests that even the most "gout associated" foods and diets accounted for less than 1% of variance in serum urate levels, while nearly 24% of variance was explained by genetic factors.

Experts in the field feel it, and evidence proves it: scabies (mange) has become a new "real-time" challenge for dermatologists, especially since the outbreak of the COVID-19 pandemic. There's been exponential growth not only in cases but also in very difficult to treat conditions, which are perpetuated above all in the family nucleus

@trombok The extent of SARS-CoV-2 binding to the ACE2 receptors is limited to the nasal and gustatory epithelial cells, with the cytokine storm remaining "low and controlled." During this stage, patients may experience smell or taste impairments, but often recover without any interventions.

The interleukin-31 (IL-31) inhibitor nemolizumab significantly improved pruritus in patients with moderate to severe atopic dermatitis in a phase 2, randomized, double-blind, placebo-controlled trial. The results support the role of IL-31 — a cytokine produced by activated T cells — in the pathobiology of atopic dermatitis and suggest that targeting elevated levels of the protein may be an effective treatment strategy. Thomas Ruzicka, MD, from the Department of Dermatology and Allergology, Ludwig Maximilian University, Munich, Germany, and colleagues report their findings online March 1 in the New England Journal of Medicine. Previously, a phase 1 clinical study showed that a single, subcutaneous dose of nemolizumab suppressed pruritus in adult patients with moderate to severe atopic dermatitis. As a result, these patients experienced less sleep disturbance related to skin discomfort, and they were able to reduce concomitant use of topical glucocorticoids.

@tishta In most cases of TS, symptoms reach their fullest expression some time during adolescence, roughly a decade after onset. At some point, symptoms become more unpredictable, sometimes changing markedly from day to day or week to week. Despite this, the later teenage years are often a time when the severity of tics levels off and remission begins. Several retrospective studies indicate that many patients, even those with severe tics during childhood, improve considerably during the late teenage to early adult years. Approximately one third of patients experience complete remissions of tics during this period, whereas another one third of patients improve to the point that their tics are relatively mild and do not cause impairment. Some evidence shows that adolescent tic severity may be of more prognostic value.

@deepangshu High costs of diabetes medications, testing supplies, and appointments, as well as difficulty receiving needed medical care for their diabetes all contribute to the gaps in diabetes care quality among people in deprived areas. As clinicians and health systems, we need to better understand the challenges our patients face every day and work with them to help them overcome them.

Hello, My underarm has turned black, what should I do? It looks very awkward. I can not wear cut sleeves. My confidence goes down. Please suggest some methods to get rid of this.

A 22 year old male from Calcutta india about 1.5-9meters above sea level had arrived for pilgrimage (Amarnat shrine pilgrimage) located at an altitude of 38884m (amaranth cave). Patient had climbed to an altitude of 3574m (sheshnag) in single day after arrival at base camp (pahalgam altitude 2740m). On night of arrival at this altitude he complained of tightness in chest, breathlessness, tiredness exhaustion, altered sensorium in form of irrelevant talking improper behaviour like refusal to feed and poor response to verbal commands. He was managed at camp site health care facility with oxygen and iv fluids, but he continued to deteriorate. How to manage this condition?