What are the diagnostic criteria for thromboangiitis obliterans (TAO) (Buerger disease)?

@achin In animal models, stress stimulates the entire immune system, bone marrow included, which leads to the hyperactive production of immune cells.

Humans with depression also produce more white blood cells, particularly monocytes. The release of these important immune cells into the bloodstream prompts further response elsewhere in the body. Inflammation is an immune response to infection or other stresses on the body. High inflammation levels are associated with autoimmune disorders and can be risk factors for cardiovascular illness or other ailments.

The Food and Drug Administration has approved collagenase clostridium histolyticum–aaes (Qwo, Endo International) for the treatment of moderate to severe cellulite in the buttocks of adult women. The drug is the first injectable treatment for cellulite to receive regulatory approval.

Roughly 16%-22% of patients with hypertension appeared to have primary aldosteronism as the likely major cause of their elevated blood pressure, in an analysis of about 1,000 Americans, which is a much higher prevalence than previously appreciated and a finding that could potentially reorient both screening for aldosteronism and management for this subset of patients.

@adrita Time-restricted feeding restored diurnal rhythms of ileal microbiome oscillations, bile acid signaling, GLP-1 signaling (which affects glucose metabolism), and circadian rhythms of transcription of protein-coding genes that were lost in mice with diet-induced obesity. Unlike other gut microbiome research, this study focused on the ileum rather than the large intestine or stool.

Ask the sibling of any celebrity and they'll tell you they don't get anywhere near the same attention. The same is true for coronaviruses – the one that causes COVID-19 has been in the spotlight for more than 2 years now, while the others at the moment circulate in relative obscurity. With the knowledge that any of the other coronaviruses could pose a serious future threat, Pfizer and its partner BioNTech announced plans on Wednesday to develop a vaccine that will work against SARS-CoV-2 (the virus that causes COVID-19) and the entire class, or family, of related coronaviruses. Trials in people of this "pan-coronavirus" vaccine are scheduled to start this fall, Reuters reported. The aim of this universal vaccine is to lessen the threat from new variants before they emerge – to provide "durable variant protection."

@manu Because no large-scale study had examined whether PTSD is associated with cognitive decline in women, the current researchers examined PTSD symptoms and their association with repeated measures of cognitive function among a large civilian trauma-exposed cohort of women aged 50 to 70 years at study baseline.

Advanced maternal age and maternal hypertension are a one-two punch that boosts the risk of cesarean births, a new study reports. While the findings presented at the 2022 annual clinical and scientific meeting of the American College of Obstetricians and Gynecologists aren’t surprising, the insight they provide can be helpful in counseling women at risk about delivery options, lead author and Loma Linda (Calif.) University maternal-fetal medicine physician Sarah D. Smithson, DO, said in an interview.

@mina-s Some patients report the onset of acute urticaria associated with the consumption of certain foods, such as shellfish, eggs, nuts, strawberries, or certain baked goods. However, food allergy is rarely the basis of chronic urticaria. Contactants may give rise to contact urticaria syndrome, a term referring to the onset of urticaria within 30-60 minutes of contact with an inciting agent. The lesions may be localized or generalized. Precipitating agents include latex (especially in healthcare workers), plants, animals (eg, caterpillars, dander), medications, and food (eg, fish, garlic, onions, tomato)