@kuheli The authors said that their study is the first report of evidence that infection with COVID-19 affects A1c levels in a large, real-world clinical cohort. Until now, the impact of COVID-19 infection on A1c remained unclear. Results from previous studies indicated that COVID-19 infection may increase A1c levels, but the studied cohorts were small and lacked uninfected controls. The current study included 8755 people infected with COVID-19, had data from both before and after the infection on diabetes status and A1c levels, and also included many matched, uninfected people who served as controls.

Vaginal delivery and breast-feeding diminish the incidence of allergy and asthma in children up to the age of 18 years, according to new research. Hill and his colleagues compared the records of 158,422 children to see how the method birth and feeding practice influenced the number of allergic conditions reported by each young person over a period of 18 years. Hill presented results from the study — which looked at atopic dermatitis, IgE-mediated food allergy, allergic rhinitis, and asthma — at American College of Allergy, Asthma & Immunology 2019 Annual Scientific Meeting in Houston.

@kankana Of these women, 36.378 (27.7%) had menstrual cycles of 26-30 days and were identified as the index group. The prevalence of NAFLD in this group was 5.8%. For those with a menstrual cycle of 31-39 days, the prevalence rate climbed to 7.2%. For those with a menstrual cycle of at least 40 days or too irregular to estimate, the prevalence was 9.7%. The prevalence was 7.1% for those with a menstrual cycle less than 21 days.

@kaberi As the relationship deepens, the pleasure that you associate with love makes you crave more. One of the wonderful things about dopamine is that it is initially only released at the time of the excitement, but then the brain is smart enough to release it in advance of the excitement — in anticipation of the hug, the kiss, or the presence of the beloved. You actually begin to feel warm before the moment of connection. That contributes to you craving it. It becomes an addiction. You want to see that person again — to connect again.

@satish Headaches are a very common condition that most people will experience many times during their lives. The main symptom of a headache is a pain in your head or face. This can be throbbing, constant, sharp or dull. Headaches can be treated with medication, stress management and biofeedback. Headache pain results from signals interacting among the brain, blood vessels and surrounding nerves. During a headache, an unknown mechanism activates specific nerves that affect muscles and blood vessels. These nerves send pain signals to the brain.

@kuheli In the first two waves, it was correct to use certain therapies as experimentation because we wanted to save lives. The key thing to remember is that we are better informed about COVID-19 treatment protocols today than ever before. Much of the treatment, especially during the second wave, was influenced by the demand of patients. There was a significant rise in convalescent plasma therapy, ivermectin and other such treatments being used. The approach should be guided by clinical protocol and perceived benefit, not a patient’s demand.

Hello, a 33-year-old white female friend is suffering from shortness of breath on exertion. She reports that she was seen for similar symptoms previously at her primary care physician’s office six months ago. At that time, she was diagnosed with acute bronchitis and treated with bronchodilators, empiric antibiotics, and a short course oral steroid taper. This management did not improve her symptoms, and she has gradually worsened over six months. She reports a 20-pound (9 kg) intentional weight loss over the past year. She denies camping, spelunking, or hunting activities. She denies any sick contacts. A brief review of systems is negative for fever, night sweats, palpitations, chest pain, nausea, vomiting, diarrhea, constipation, abdominal pain, neural sensation changes, muscular changes, and increased bruising or bleeding. She admits a cough, shortness of breath, and shortness of breath on exertion. How to recover this condition?

@kuheli When investigating a patient with pyrexia of unknown origin (PUO), consider possible aetiologies in each of the following four broad categories: infective, inflammatory, neoplastic and miscellaneous. Address each in turn. Pyrexia of unknown origin is a diagnostic challenge and early involvement of specialists is important.
The balance of causes of PUO varies over time and across different patient populations.
Investigations should be undertaken based on the most likely cause(s). Blanket investigations are not recommended as positive or equivocal tests are difficult to interpret in the absence of a suggestive exposure history and/or clinical syndrome. This can be misleading and potentially cause patient harm.
Empirical therapeutic trials are not recommended before a diagnosis is made, unless the patient is believed to have miliary tuberculosis (TB), central nervous system TB, temporal arteritis or infective endocarditis with severe sepsis.
The overall outcome of patients with a PUO is good, especially when no cause is found