@abhishikta As mentioned in the PLOS Medicine report, the TARGET trial was conducted at 10 maternity hospitals in New Zealand between May 2015 and November 2017. A total of 1100 women diagnosed with GDM at 22 to 34 weeks' gestation were enrolled, along with their 1108 infants. Every 4 months, two hospitals moved from using less stringent targets to tighter targets. Overall, 598 (55%) women (602 infants) were included while their hospital was allocated to the use of tighter targets, and 502 (45%) women (506 infants) were included while their hospital was allocated to the use of less stringent targets.

A home-based palliative care program involving primary care physicians, cardiologists, and palliative care specialists is associated with a lower likelihood of dying in the hospital for patients with chronic heart failure, data indicate. The program is also associated with fewer visits to the emergency department, more clinician home visits, shorter hospital stays, and more days spent at home.

@simran The investigators evaluated this link by comparing 9,823 cases of Parkinson's disease with 8,376 controls, all individuals of European ancestry from the Courage-Parkinson's disease consortium, comprising 23 studies. Data were analyzed by two-sample Mendelian randomization, a technique that uses genotype to predict behavior, thereby replacing conventional methods of capturing behavior, such as questionnaires. In this case, the investigators screened all participants for rs4988235, a single-nucleotide polymorphism (SNP) upstream of the lactase gene that is well documented to predict dairy intake among individuals of European ancestry.

Patients with persistent cognitive impairment months after illness with mild COVID-19 have higher levels of inflammatory markers in their cerebrospinal fluid (CSF). Researchers found elevated levels of CSF immune activation and immunovascular markers in individuals with cognitive post-acute sequelae of SARS-CoV-2 infection (PASC). Patients whose cognitive symptoms developed during the acute phase of COVID-19 had the highest levels of brain inflammation. The findings add to a growing body of evidence that suggests the condition often referred to as "brain fog" has a neurological basis, said lead author Joanna Hellmuth, MD, MHS, assistant professor of neurology at the University of California, San Francisco Weill Institute of Neurosciences and the UCSF Memory and Aging Center. The findings will be presented at the American Academy of Neurology (AAN) 2022 Annual Meeting on Thursday.

Vitamin D deficiency has been linked to an increased risk for schizophrenia, new research shows. A review of 19 studies, which included more than 2800 participants, showed that those with vitamin D deficiency were more than twice as likely to be diagnosed with schizophrenia compared with their counterparts who were not vitamin D deficient. In addition, 65% of the patients who had schizophrenia also had lower levels of vitamin D.

Severe food insecurity was associated with metabolic syndrome and unfavorable cardiometabolic markers in Hispanic/Latino youth, researchers report. The findings, published March 16 in Pediatrics, highlight the need to investigate interventions that address food insecurity among Hispanic/Latino youth, a segment of the U.S. population at high risk of cardiometabolic complications.

@simran Before you get a tattoo, think carefully about it. If you're unsure or worried that you might regret it, give it more time. Don't allow yourself to be pressured into getting a tattoo, and don't get a tattoo if you're under the influence of alcohol or drugs. Choose the location of the tattoo carefully. Consider whether you want the option to hide your tattoo under clothing. Also remember that weight gain — including pregnancy weight gain — might distort the tattoo or affect its appearance. To make sure your tattoo will be applied safely, ask these questions:
Who does the tattooing? Go to a reputable tattooing studio that employs only properly trained employees. Keep in mind that regulation requirements and licensing standards vary from state to state. Check with your city, county or state health department for information on local licensing and regulations.
Does the tattoo artist wear gloves? Make sure the tattoo artist washes his or her hands and wears a fresh pair of protective gloves for each procedure.

@awanish Chatbots are AI-backed computer applications (sometimes not full-blooded AI but sophisticated algorithms) conducting human-like meaningful conversations via voice, textual, or option-based input. They are becoming popular and widespread in every industry, including healthcare and medical consulting. Such solutions, accessible 24/7 online or via mobile devices, are capable of preliminary medical diagnostics and health advisory based on a patient’s inputs and complaints. Chatbots can also be integrated with custom patient portals for hospitals and clinics. They can help patients address their health conditions and concerns, even for acute conditions, when human medical assistants are out of reach for some reason (such as disaster-induced overloads of call centers, peak or non-operation hours, etc.). Such chatbots can help patients to identify their next steps and encourage them to seek qualified medical assistance when necessary. However, care must be taken as they can lead to misinformation and incorrect self-diagnosis. We’ve all been there!

Hello, I am 21 years old. I am obese and overweight. Doctor has advised me to cut down my body weight, otherwise I will be diseased very soon. So I have joined a gym near my place. After my first day in gym, I have become very low. I am having body ache. I can't move or lie down. It is paining a lot. Please advise on How to manage body ache after going to gym for first time. Shall I go to see doctor again?

Hello, my wife is 45 years old. She is hypertensive also. She used to have headaches, shortness of breath and nosebleeds. Doctor has prescribed her calcium channel blocker to bring down blood pressure to normal along with life style changes. She is taking it regularly. I am trying to look for the mechanism of action of calcium channel blocker with its any specified adverse effect. Please let me know.