The investigational once-weekly insulin icodec (Novo Nordisk) significantly reduces A1c without increasing hypoglycemia in people with type 2 diabetes, the first Phase 3 data of such an insulin formulation suggest. The data are from one of six trials in the company's ONWARDS program.

@kulwinder It is clear that if you are isolated, for example, living alone and not confiding in others, then you may be suffering from chronic stress through relying on only yourself, with no one to help you or with whom to discuss your problems.

@honey The researchers studied data from participants (n = 1365; mean age, 77.9 ± 3.7 years) in the Women's Health Initiative Magnetic Resonance Imaging Study (WHIMS-MRI), which focused on community-dwelling older women who had undergone brain MRI between April 2005 and January 2006. Of these participants, 730 underwent a second scan during the period 2010–2013. The average amount of time between scans was 4.77 years.

@nilanjana Colonoscopy is a durable screening and surveillance strategy, but it's not perfect [because] it depends on a physician's skill and their ability to pick up polyps in the colon. During routine colonoscopy, the GI Genius system generates visual markers ― essentially, small green squares — and a low-volume sound whenever the software detects a region of interest. These squares are superimposed on the video generated by the endoscope camera to alert the colonoscopist to regions that may require closer assessment, either visually, by tissue sampling, or by removal of the lesion itself.

@pritam The OAS1 gene is expressed in microglia, a type of immune cell that makes up around 10% of all cells in the brain. In earlier work, investigators found evidence suggesting a link between the OAS1 gene and AD, but the function of the gene in microglia was unknown. To further investigate the gene's link to AD, they sequenced genetic data from 2547 people ― half with AD, and half without. The genotyping analysis confirmed that the single-nucleotide polymorphism (SNP) rs1131454 within OAS1 is significantly associated with AD. Given that the same OAS1 locus has recently been linked with severe COVID-19 outcomes, the researchers investigated four variants on the OAS1 gene. Results indicate that SNPs within OAS1 associated with AD also show linkage to SNP variants associated with critical illness in COVID-19.

Years spent caring for a dog or cat may help mitigate cognitive decline among older adults, new research suggests. In a large study of Medicare beneficiaries, pet owners had slower cognitive decline over 6 years than their peers who did not care for a pet. Previous research has studied the impact of pets on overall health, mood, and quality of life; but to our knowledge, our study is the first to consider the effect of duration of pet ownership on cognitive health in older adults age 65 and older. Although the study could not prove a cause-and-effect relationship, the findings do provide early evidence suggesting that long-term pet ownership may protect against cognitive decline.

@papiya Inflammation of the deeper structures of the eye, particularly the sclera and the iris, is rare but serious. There is often a correlation with autoimmune disorders, and eye symptoms can be the first manifestation of a systemic, potentially life-threatening, disease. About 40% of patients with scleritis have underlying rheumatologic diseases. And red eye can be an early indication of spondyloarthropathy or ankylosing spondylitis in young men with anterior uveitis (iritis or iridocyclitis). In cases of inflammation, consultation with an ophthalmologist or rheumatologist could lead to the early initiation of therapy, improving disease prognosis.

Contrary to conventional clinical wisdom, greater body fat is associated with lower bone mineral density (BMD), particularly in men, an analysis of data from a large, nationally representative sample has found. Much previous research has suggested that obesity protects against fractures and loss of BMD for a variety of reasons, including the beneficial effects of weight-bearing on the skeleton and hormonal factors linked to body fat. But the new findings should prompt a reconsideration of the relationship between obesity and fracture risk, according to the investigators, whose study appears in the latest issue of the Journal of Clinical Endocrinology & Metabolism.

@manpreet Cut a potato in half, rub it all over your hands, then follow up with soap and cold water. The folks at Cook’s Illustrated have tested and recommend using a potato half to de-garlic a wood cutting board, saying foods that brown (like apples and potatoes) have an enzyme (polyphenol oxidase) that “can oxidize sulfurous compounds, including the thiols and thiocyanates that give garlic its pungent odor, turning them into odorless compounds.” If it works on wood, why not human skin? Plus, lots of websites stand behind the hack. Pour a scoop of coffee grounds into the palm of your hand, add a few drops of water and rub your hands together, exfoliating your skin for 30 seconds. Follow with soap and cold water. Coffee grounds are a known odor absorber; Food & Wine even recommends drying your used coffee grounds in order to reuse them to soak up smells in the fridge, kitchen cabinets, even in the bathroom.

@sreejon This medication is used with other drugs to treat tuberculosis (TB) infections. Capreomycin belongs to a class of drugs known as antibiotics. It is believed to work by preventing the growth of the bacteria that causes TB. This medication is given by injection into a muscle or infused into a vein over 1 hour, usually by a health care professional. It is usually given once a day for 2 to 4 months then reduced to 2 or 3 times a week depending on your condition and response to treatment, or use as directed by your doctor. Dosage is based on your medical condition, kidney function, and response to treatment.
If you are using this medication at home, learn all preparation and usage instructions from your health care professional. If you have any questions about using this medication properly, ask your health care professional. Before using this product, check it visually for particles. When mixed, this medication may be nearly colorless or very pale yellow. The color may darken over time, but this does not make this medication less effective. If the liquid has particles or has changed to any other color than pale or dark yellow, do not use it.