Despite greater focus on pediatric palliative and supportive oncology services in the United States, children with cancer may not be receiving high-quality end-of-life care. Many children with advanced cancer report incredible pain, fatigue, and nausea near the end of life, and over 60% of children with cancer die in the hospital, despite evidence that most families prefer to be at home.

@addis The presence of high platelets is rarely associated with a medical emergency. However, in some cases, high platelets may cause blood clotting, bleeding or stroke. If high platelets are accompanied by a persistent headache, difficulty breathing, dizziness, seizures, changes in speech, or confusion or loss of consciousness.

@manu n 2020, the Food and Drug Administration approved subcutaneous injections of CCH (marketed under the brand name QWO) for treatment of cellulite in women's buttocks on the basis of the randomized RELEASE-1 and -2 trials. But while this is a new indication for CCH, it is not a new drug. The medication has been approved for years for treatment of fibrotic band contracture disorders, namely Dupuytren's contracture and Peyronie's disease. The mechanism of action for treatment of cellulite involves a process dubbed enzymatic subcision, in which CCH breaks down mature collagen and stimulates new collagen formation and fat redistribution in an effort to achieve smoother skin contour.

Children and adolescents with migraine are about twice as likely to have an anxiety or depressive disorder as those without migraine, results from a new review and meta-analysis suggest. This is compelling, high-level evidence showing there's this established comorbidity between migraine and anxiety and depressive symptoms and disorders in this age group

@debniv This newer approach, transcutaneous auricular VNS, is non-invasive, is well tolerated, and has shown initial efficacy in major depression in men and women