Sodium-glucose cotransporter-2 (SGLT2) inhibitors may reduce the risk for gout among adults with type 2 diabetes, new research suggests. The study, involving more than 200,000 individuals from a US commercial insurance database, was published online January 13 in Annals of Internal Medicine by Michael Fralick, MD, PhD, and colleagues. The glycosuria produced by SGLT2 inhibitors results in secretion of uric acid into the urine and a reduction in serum uric acid levels, but a relationship with gout had not been previously shown.

@abhinav It's important to remember that this includes new cases, as well as retrospectively identified cases. Over half (52%) are from the European region, while 262 cases (30% of the global total) are from the United Kingdom. Together the United Kingdom and the United States make up 65% of the global total.

The risk of cardiovascular events in patients with psoriatic disease rises with higher levels of two cardiac biomarkers in a manner independent of risk calculated by the Framingham Risk Score (FRS), a longitudinal cohort study has shown. But researchers who conducted the study note that neither of the two biomarkers identified in the study ― cardiac troponin I (cTnI) and N-terminal pro-brain-type natriuretic peptide (NT-proBNP) ― led to an improvement in predictive performance when combined with the FRS, despite their association with carotid plaque burden.

Berries, red wine, and other foods rich in flavonoids are associated with a lower risk for death in patients with Parkinson's disease (PD), new research suggests. In a prospective analysis of more than 1200 participants with an eventual PD diagnosis, those who ate three or more servings of flavonoid-rich foods a week had a 70% lower mortality vs those consuming one or fewer servings of such foods per month.

Atopic dermatitis may be more prevalent in adults than previously realized, in part because it is a difficult diagnosis to make. Atopic dermatitis is often referred to as eczema by lay people and by healthcare professionals, but the term is too imprecise. Data from a previous study showed that patients who, as children, developed atopic dermatitis that persisted into adulthood exhibit null mutations in the filaggrin gene, but that these mutations are not associated with those whose dermatitis began in late childhood or adulthood

Even though men in midlife have more cardiovascular (CV) conditions and risk factors than women of the same age, women are more affected by these conditions in terms of cognitive decline, new research suggests. Analyses of almost 1400 participants in the population-based Mayo Clinic Study of Aging showed that diabetes, dyslipidemia, and coronary heart disease (CHD) all had stronger associations with global cognitive decline in women than in men

@arata Dark areas of skin may occur when pigment cells in the skin multiply faster than usual. This can occur as a result of repeated hair removal. Regularly shaving the underarms can lead to excessive production of pigment cells. The dark color itself is not usually a cause for concern. However, some people dislike having dark underarms for cosmetic reasons and may wish to try using the following methods to treat them:
moisturizing
applying topical creams
having laser therapy
using natural remedies, such as lemon juice or sea cucumber extract

Hello, I am suffering from urticaria, any suggestion to cure? I have itchy feeling round the clock. Please suggest any help so that I can mitigate the symptom.

@deepjoy-0 Vitamin A deficiency results from a dietary intake of vitamin A that is inadequate to satisfy physiological needs. It may be exacerbated by high rates of infection, especially diarrhoea and measles. It is common in developing countries, but rarely seen in developed countries. Vitamin A deficiency is a public health problem in more than half of all countries, especially those in Africa and South-East Asia. The most severe effects of this deficiency are seen in young children and pregnant women in low-income countries. Vitamin A deficiency can be prevented through a diet which includes:
Spinach, kale, collards, brocolli and other leafy green vegetables
Beta-carotene-rich fruits such as apricots or peaches, and highly-coloured vegetables such as carrots, squash, sweet potato
Milk or cereals that have been fortified with vitamin A
Liver
Egg yolks
Fish liver oils

An 18-year-old man was referred for evaluation of delayed puberty. History revealed that he had never grown facial, axillary or pubic hair, his voice had not changed, and he rarely had acne or body odour. His mother recalled that he was quite small as a young child but, after five years of age, seemed to grow normally. She also reported that his energy level was quite low and he rarely left the house except for school. He missed approximately five days of school each month because of illness.