@ricky Results from a CSF amyloid oligomeric assay to determine target engagement as well as pharmacokinetic/pharmacodynamic analyses to measure drug exposure are still in progress.

Spinraza (nusinersen) has been approved by the FDA and is now available for treatment of patients with SMA due to SMN1 mutations. The CUIMC - SMA Clinical Research Center was the first site in the world to administer Spinraza in a clinical trial. Patients who meet the following criteria may be eligible for treatment with Spinraza:

Patients who have genetically confirmed SMA and meet the medical criteria for treatment.
Patients who are registered and receiving care with a ColumbiaDoctors provider.
Patients who are able to follow-up with their ColumbiaDoctors provider after treatment.
Patients who can be evaluated by their ColumbiaDoctors provider, including physicians and nurse practioners, six months after receiving their Spinraza treatment.

In a first of its kind study, researchers found women who received two mRNA COVID vaccine doses during pregnancy were 61% less likely to have a baby hospitalized for COVID-19 during the first 6 months of life. In addition, two doses of the Pfizer/BioNTech or Moderna COVID vaccine later in a pregnancy were linked to an even higher level of protection, 80%, compared with 32% when given before 20 weeks' gestation. This finding suggests a greater transfer of maternal antibodies closer to birth, but more research is needed, cautioned senior study author Manish Patel, MD, during a Tuesday media telebriefing held by the Centers for Disease Control and Prevention (CDC). Unanswered questions include how the babies got infected or if there is any protection afforded to babies for women vaccinated before pregnancy.

@milan Obesity is a known risk factor for impaired glucose metabolism and for gestational diabetes. American College of Obstetricians and Gynecologists (ACOG) currently recommends early screening for gestational diabetes in patients with certain risk factors, including obesity, a history of first-degree relatives with diabetes, or a history of gestational diabetes, impaired glucose tolerance, poor pregnancy outcomes, fetal demise, congenital abnormalities, or birth of an infant large for gestational age.

Hello, I would like to know how to get rid of ear wax. My brother is having this issue. He has got lot of ear wax. It sometimes itches and causes problem in hearing also. How to dissolve this wax? Please leave your comments on this.

Hello, How does robotic surgery function in medical care? Robotics has been making an impact on medical care since the 1980s, but as the technology behind it has improved, the applications have increased exponentially. Please leave your comments on this.

Hello, I am suffering from food poisoning, what should I do? I have diarrhea, throwing up, and an upset stomach. There’s not a whole lot I can do except stay near a bathroom and ride it out. Please help me with your suggestions.

Hi, I am 25 years old and I am really worried about thinning my hair. Is there anything I can do to stop it?

Hi I want to know how much sunscreen should I use and how should I apply it?

Hi I am 30 years old and want to know are fibroids cancerous and what is the cause of it?