Using artificial intelligence (AI), researchers have developed an algorithm that can help improve the prediction of colorectal cancer (CRC) recurrence. The QuantCRC algorithm can identify patients with CRC who might be able to skip chemotherapy, given a low probability of recurrence, and identify those patients at high risk for recurrence who may benefit from more intensive treatment or follow-up, the researchers say.
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AI Tool May Improve Prediction of Colorectal Cancer Recurrence
RE: Glucagon Analog Stops Hypoglycemia Faster Than Carbs
@somraj Faster action and a higher rate of resolution may, in part, explain the high level of satisfaction with dasiglucagon by patients in the study. When the researchers asked participants at the end of the open-label study how likely they were to use dasiglucagon as part of their diabetes management, 88% said they would be very likely to continue using the agent, with an additional 8% saying that they would likely use it,
From Cradle to Grave, Alcohol Is Bad for the Brain
There is "compelling" evidence of the harmful effects of alcohol on the brain. The greatest risk occurs during three periods of life that are marked by dynamic brain changes, say researchers from Australia and the United Kingdom. The three periods are
Gestation (conception to birth), which is characterized by extensive production, migration, and differentiation of neurons, as well as substantial apoptosis;
Later adolescence (age 15 to 19 years), a period marked by synaptic pruning and increased axonal myelination; and Older adulthood (age 65 and beyond), a period associated with brain atrophy. Changes accelerate after age 65, largely driven by decreases in neuron size and reductions in the number of dendritic spines and synapses.
FDA Approves Video Game-Based Therapy for Kids With ADHD
The US Food and Drug Administration (FDA) has allowed marketing of a "prescription-only game-based" digital therapeutic device for children aged 8 to 12 years who have primarily inattentive or combined-type attention-deficit/hyperactivity disorder (ADHD) and problems with inattention. The EndeavorRx device (Akili Interactive) is indicated for the improvement of attention function, as assessed by computer-based testing. It is the first device of its kind to be approved for this indication and is the first video game–based therapeutic device to receive marketing authorization from the FDA for any condition, according to an FDA news release. "The device is intended for use as part of a therapeutic program that may include clinician-directed therapy, medication, and/or educational programs, which further address symptoms of the disorder," the FDA explains in a news release.
Certain Cancers Increase Stroke Risk, New Analysis Confirms
A new systematic review revealed that people living with certain cancers as well as those in remission face a significantly higher risk for stroke than people with no history of cancer. Previous research has suggested such a link exists, but until now, the evidence has not been robust enough to elicit guidelines on stroke risk and prevention in cancer patients.
New Data Support Electroconvulsive Therapy for Depression
Advocates and users of electroconvulsive therapy (ECT) have received further scientific backing: a retrospective cohort study has provided further evidence that ECT can prevent suicide among severely depressed patients. The patient cohort comprised 27,231 men and 40,096 women who had been treated as inpatients. The average age was 45.1 years (range: 18-103 years), and 4982 patients received ECT. The primary endpoint was death by suicide within 365 days of hospital discharge. The secondary endpoints were death not by suicide and total mortality. The cause-specific hazard ratio (csHR) was calculated for patients with ECT, compared with patients without ECT. In the propensity score-weighted analysis, ECT was linked to a significantly reduced suicide risk (csHR: 0.53; 95% CI, 0.31 - 0.92). According to the calculations, ECT was associated with a significantly decreased total mortality risk (hazard ratio, 0.75; 95% CI, 0.58 - 0.97). However, this was not the case for death from causes other than suicide.
RE: Strawberries, Spinach, Kale: High on the 'Dirty Dozen' List
@nivaan To produce the report, the Environmental Working Group analyzed more than 44,000 samples taken by the FDA and USDA, which tests a subset of produce each year. Before testing, USDA scientists prepare each fruit or vegetable the way people tend to do themselves, such as peeling those with inedible peels and rinsing produce with edible peels. The Environmental Working Group takes six measures of pesticide contamination into account:
Percent of samples tested with detectable pesticides
Percent with two or more detectable pesticides
Average number of pesticides in a single sample
Average amount of pesticides, expressed in parts per million
Maximum number of pesticides on a single sample
Total number of pesticides found.
Immediate Postpartum IUD Insertion Increases Expulsion!
Expulsion of intrauterine devices was significantly more likely when the devices were inserted within the first 3 days after delivery compared with later insertions, based on data from more than 300,000 women. Intrauterine devices are effective contraception, and current guidelines support immediate postpartum IUD insertion as a safe, effective, and convenient option, Mary Anne Armstrong, MA, of Kaiser Permanente Northern California, Oakland, and colleagues wrote. Although IUD expulsion rates are low overall, data from previous studies suggest that timing of insertion may affect expulsion rates, and that breastfeeding may play a role.
RE: Why Is Vitamin D Hype So Impervious to Evidence?
@pipasha It has long been known that vitamin D is crucial for bone health and that it can be produced in the skin with sun exposure. In the last decade, however, experts note that nearly every tissue and cell in our body has a vitamin D receptor. It then follows that if this many cells in body can activate vitamin D, it must be vital for cardiovascular health, immune function, cancer prevention: basically, everything health-related. Oodles of observational studies have found that low serum levels of vitamin D correlate with higher mortality from all causes, cancer, cardiovascular disease, and now even COVID-19. Yet no matter the amount of statistical adjustment in these studies, we cannot know whether these associations are due to true causality. The major issue is confounding: that is, people with low vitamin D levels have other conditions or diseases that lead to higher rates of ill health. Consider a patient with obesity, arthritis, and cognitive decline; this person is unlikely to do much exercise in the sun and may have low vitamin D levels. The low vitamin D level is simply a marker of their overall poor health.
Does drinking warm water provide protection from COVID 19?
According to a TV report, hot water bath or drinking warm water prevent Covid-19. Although the government has said that it does not kill the virus nor does it cure the disease. It added that a temperature of 60-75 degrees is required to kill the coronavirus in lab settings. Please need some clarity on this.