Psychiatric patients with impaired communication abilities were significantly more likely to be admitted involuntarily to inpatient care and to experience coercive measures after admission, based on data from more than 1,500 individuals. Despite improvements in reducing coercive measures in psychiatric inpatient care, both involuntary admission and coercive measures remain in use in many countries worldwide

The US Food and Drug Administration (FDA) has approved Abbott Laboratories’ new Proclaim Plus spinal cord stimulation (SCS) system featuring FlexBurst360 therapy for the treatment of patients with chronic pain. The "next generation" of its proprietary BurstDR stimulation, FlexBurst360 therapy, provides pain coverage across up to six areas of the trunk and limbs, with programming that can be adjusted as a patient's individual therapeutic needs evolve

@satyajit A vaccine that probably will be effective is currently available, even if in short supply. Antiviral medications, like tecovirimat, are available for people with severe infections, such as proctitis, or for those who are immunosuppressed. However, we lack clear-cut evidence that these drugs are helpful in most patients.

@rekha Searching for compounds that might achieve this goal, he came across literature on T wilfordii Hook F, commonly known as lei gong teng. or thunder god vine. Practitioners of traditional Chinese medicine use it to treat rheumatoid arthritis and other autoimmune and inflammatory diseases. He said that with more than 3 months of use, it can cause male infertility. It appears to interrupt the development of the sperm, causes malformations, and lowers sperm counts and motility.

A novel treatment for amyotrophic lateral sclerosis (ALS) that targets brain cell energy production to promote remyelination showed signs of efficacy in a phase 2 trial, though it did not meet its primary endpoint, which was the change in the summated motor unit index (MUNIX) from baseline to week 36. The drug, CNM-Au8, is being developed by Clene, and would represent a novel mechanism of action. "This is a brand-new approach. We used it complementary with riluzole and it was well tolerated, so I see this as an add-on therapy. I think if we can show some more positivity and longer-term results, it's going to be a game changer for ALS," Matthew Kiernan, MBBS, PhD, said in an interview. Kiernan presented the results at the 2022 annual meeting of the American Academy of Neurology.

@sandesh n an attempt to connect peripheral metabolic changes and brain changes in AD, Nho and colleagues analyzed data on 1562 older adults with early-stage AD or who were at risk for AD from the Alzheimer's Disease Neuroimaging Initiative cohort. They assessed the association of bile acids with CSF biomarkers and neuroimaging biomarkers, including brain atrophy measured by MRI and brain glucose metabolism measured by fluorodeoxyglucose positron emission tomography. First, lower serum concentrations of primary bile acids synthesized in the liver from cholesterol were significantly associated with worse cognitive function, decreased hippocampal volume, and decreased brain glucose metabolism. Second, higher serum concentrations of secondary bile acids produced in the gut by bacteria were significantly associated with higher CSF phosphorylated tau and CSF total tau levels, as well as larger brain structural atrophy and decreased brain glucose metabolism.

@sandesh Decades of research have shown that cutting tobacco use is the single most powerful way to prevent many deadly cancers, especially in developing countries where smoking is most widespread. Tackling obesity, a key modifiable risk factor for many cancers, is another top prevention priority.

@sandesh Better understanding of the neurobiology of cognitive impairment in depression can provide new targets for developing more specific treatments, not only for its prevention and treatment but also for its downstream negative outcomes, including the development of dementia and related disorders," she added in a release. Whole-blood samples were taken from all participants and tested for the proteins associated with pathways for cancer, cardiovascular disease, metabolic syndrome, psychiatric disorders, and neurodegenerative disorders.

@satyajit Chronic kidney disease (CKD) patients may be at increased risk for atherosclerotic cardiovascular disease, but no ASCVD risk prediction models are currently in place to inform clinical care and prevention strategies, Joshua Bundy, PhD, of Tulane University, New Orleans, and colleagues wrote in their paper, published in the Journal of the American Society of Nephrology. To improve the accuracy of ASCVD risk prediction, the researchers developed several models using data from the Chronic Renal Insufficiency Cohort (CRIC) study. This longitudinal cohort study included more than 2,500 adult CKD patients. The participants' ages ranged from 21-74 years, with the mean age having been 55.8 years, and 52.0% of the cohort was male.

My husband has a foul smelling sneeze. What should be the reason? What should I do? It is really pretty bad. Please provide some inputs.