@diptangshu As seltorexant is an orexin receptor antagonist, it is related to other medications that are marketed as sleeping pills, so it was important to show that its antidepressant efficacy was actually caused by improved sleep.

@premomay The researchers enrolled 1522 participants with MDD (85.25% men; mean age, 54.4 years) from 35 US VA health centers. All were randomly assigned to receive aripiprazole in addition to current treatment ("+aripiprazole," n = 505), bupropion in addition to current treatment ("+bupropion," n = 506), or bupropion by itself ("switchers," n = 511) for 12 weeks. Follow-up evaluations were conducted for up to 36 weeks. The primary outcome was remission, defined as a score of 5 or less on the 16-item Quick Inventory of Depressive Symptomatology–Clinician Rated (QIDS-C) on two consecutive visits. Secondary endpoints included response rates, defined as a 50% or greater reduction in QIDS-C score or a rating on the Clinical Global Impression (CGI) scale indicating the patient was much or very much improved; relapse rates during the follow-up phase; and any treatment-related adverse events.

@souptik Like hydrogen peroxide, rubbing alcohol can help kill off the fungus that's on the surface level of the skin. You can apply it directly to the affected area or soak your feet in a footbath of 70 percent rubbing alcohol and 30 percent water for 30 minutes. It kills the fungus causing the infection, besides keeping the affected area dry. Dip a cotton ball in 90 per cent isopropyl alcohol and dab on the area. Do not wash off the alcohol as it will evaporate by itself. Repeat twice-thrice daily.

Hello, my grandmother is 83 years old. She is suffering from Parkinson's disease. Her conditions are not improving at all. Please let me know the management options for Parkinson's disease.

Hello, my friend's daughter is a 10 year-old girl. She has a 3-week history of sore throat leading to significantly decreased oral intake. She reports progressive worsening of a painful sore throat resulting in avoidance of nearly all oral intake. She had lost 22-lb weight also. How to cure her acute tonsillitis?

50-year-old female with type 2 diabetes developed severe pain in the abdomen and leg as well as unintentional weight loss. The patient was a high-functioning executive who was unable to work for six months due to pain and fatigue. The patient had a history of uncontrolled diabetes for eight years without any other complications. Her hemoglobin A1C was 13 percent (the goal is < 7 percent for optimal control). Followed by she had lowered her hemoglobin A1C to 6.7 percent. Although she had better control of her diabetes, she was still experiencing excruciating pain. At home in Michigan, she consulted a neurologist, a rheumatologist and a pain specialist. She was prescribed several medications, including opioid pain medicine. However, her symptoms continued to progress for six months, leaving her unable to walk, eat or sleep.