@sanian This is one of the first studies where in humans the relation between timing of physical activity and insulin resistance was examined.

Patients with both nasal and ocular symptoms of seasonal allergic rhinitis (SAR) have a new treatment option that combines olopatadine hydrochloride and mometasone furoate in the form of a nasal spray. Ryaltris (Hikma Pharmaceuticals PLC and Glenmark Pharmaceuticals Ltd) is approved by the US Food and Drug Administration for adults and children aged 12 years and older and has an onset of action of within 15 minutes for nasal symptoms, according to a company press release.

@chandi Devices are also useful for patients with diabetes. Many of them email results from their glucose monitors to Radhakrishnan so she can keep an eye on their highs and lows, and have them come for an office visit only when necessary.

A novel blood test that can detect up to 50 different cancers from a single blood draw is gaining traction in the United States. The Galleri blood test is being now offered by a number of US health networks. The company marketing the test, GRAIL, has established partnerships with the US Department of Veterans Affairs, Mercy Health, Ochsner Health, Intermountain Healthcare, Community Health Network, Knight Cancer Institute at Oregon Health & Science University, Premier, and Cleveland Clinic, among others.

@rajdeep The symptomatology of anxiety NOS included psychological distress about the PD diagnosis, insecurity about the future, fear of losing control of motor and bodily functions, and social embarrassment. Clinically, anxiety NOS was associated with a range of factors including minor depression, on-off motor symptoms, muscle cramps, poor quality of life, and gait impairment. The symptomatology of fluctuating anxiety was assessed in 9 studies of the "on" motor state and 16 studies of both "on" and "off." Symptoms associated with the off state included panic attacks, feeling anxious or sad, and avoiding situations, as well as palpitations, dizziness, chills, and hot flashes. Clinically, studies showed that anxiety was more severe in the off-medication state, and symptoms were reduced in the on state. Data from some studies showed that fluctuating anxiety was more common in PD patients who were female, and who had a younger age of PD onset and longer disease duration.

@milind The study did not address the definitive amount of time of breastfeeding and its correlation to the improvement of CVD risk, but it did show that for the lifetime duration, the longer the better. Clinicians and employers must provide ways to educate women about breastfeeding and make it easy for women who are in the workplace to pump, and to provide them with resources where possible

Having depressive symptoms speeds cognitive decline, but the relationship is not due to the presence of β-amyloid, tau tangles, or other brain pathology, results of a new postmortem study suggest. Researchers have known for some time that depression is related to elevated risk for mild cognitive impairment (MCI) and dementia, but they haven't agreed on why this is the case. Many in the field were convinced that the relationship is driven by underlying cognitive issues and that people become depressed as a result of getting more demented

The indirect effects of the COVID-19 pandemic on clinical practice have received great attention, but evidence regarding thyroid disease management is lacking. Levothyroxine, a medication used to treat both overt and subclinical hypothyroidism, has been commonly prescribed worldwide. Ample evidence has shown that, if untreated or uncontrolled, such hypothyroid status increases the risk of long-term adverse health outcomes (eg, cardiovascular disease and death). Recent reports in the literature have suggested a possible link between COVID-19 and thyroid disorders, such as subacute thyroiditis related to SARS-CoV-2 and severe complications due to SARS-CoV-2 in uncontrolled thyrotoxicosis.

Hello, Does ice act as anesthetic? Please explain elaborately the mechanism of action behind this. I learnt that briefly applying an ice cube to the skin could diminish the pain. Please leave your comments.

@sushmita Tachycardia may not cause any symptoms or complications. But if left untreated, some forms of tachycardia can lead to serious health problems, including heart failure, stroke or sudden cardiac death. Treatment for tachycardia may include specific maneuvers, medication, cardioversion or surgery to control a rapid heartbeat. The goals of tachycardia treatment are to slow a rapid heartbeat when it occurs and to prevent future episodes of a fast heart rate. If another medical condition is causing tachycardia, treating the underlying problem may reduce or prevent episodes of a fast heartbeat. A fast heart rate may correct itself. But sometimes medication or other medical treatments are needed to slow down the heartbeat. Ways to slow a fast heart rate include:
Vagal maneuvers. Vagal maneuvers include coughing, bearing down as if having a bowel movement and putting an ice pack on the face. Your health care provider may ask you to perform these specific actions during an episode of a fast heartbeat. These actions affect the vagus nerve, which helps control the heartbeat.
Medications. If vagal maneuvers don't stop the fast heartbeat, medication may be needed to restore the heart rhythm.