@nibhriti This really adds to the evidence that hypertensive disorders of pregnancy are an important risk factor for cardiovascular disease and possibly cardiovascular disease mortality. And the important message for a clinical audience is that it doesn't have to go through chronic hypertension

@neel Currently, the gold standard in PD is to look at motion-based symptoms, whereas the evidence points to a very strong connection" between PD and nocturnal breathing

The discovery of cancer-causing BRCA1/2 mutations and the emergence of genetic testing have brought precision in patient selection for poly-(ADP)-ribose polymerase inhibitor (PARPi) treatment. Interestingly, patients who are carriers of BRCA1/2 mutations have a higher risk for developing cancer, but respond better to DNA-damaging cytotoxic therapy, such as platinum-based chemotherapy. The distinctive biology of ovarian cancer involves high genomic instability consisting of gene amplification, gene deletion, oncogene hypomethylation, loss of heterozygosity, and tumor suppressor gene promoter hypermethylation in many of the DNA damage response (DDR) genes, including BRCA1/2. Several of these genetic abnormalities can impair high fidelity DNA damage repair increasing the therapeutic audience for PARPi's. This is especially important given the clinical development over the last decade of this group of agents and the dramatic increase in progression free survival among ovarian cancer patients who received PARPi, both in treatment or maintenance setting.

@srabanti Sunscreens have traditionally been divided into chemical absorbers and physical blockers on the basis of their mechanism of action. Chemical sunscreens are generally aromatic compounds conjugated with a carbonyl group. These chemicals absorb high-intensity UV rays with excitation to a higher energy state. The energy lost results in conversion of the remaining energy into longer lower energy wavelengths with return to ground state. Inorganic particulate sunscreens, zinc oxide, and titanium dioxide, can reflect or scatter UVR. Micronized forms of physical blockers may also function by absorption. Allowable ingredients and maximum allowable concentrations, as listed in the FDA monograph, are shown in the Table below. Europe, Australia and Japan allow additional active ingredients. In 2014, the US Congress passed the Sunscreen Innovation Act to establish an expedited review process to allow approval of additional sunscreen ingredients. To date, no new ingredients have been approved, several of which have been used in Europe for over a decade.

@niyam Most people have headaches from time to time. But if you have a headache more days than not, you might have chronic daily headaches. Rather than a specific headache type, chronic daily headaches include a variety of headache subtypes. Chronic refers to how often the headaches occur and how long the condition lasts. The constant nature of chronic daily headaches makes them one of the most disabling headache conditions. Aggressive initial treatment and steady, long-term management might reduce pain and lead to fewer headaches. chronic daily headaches occur 15 days or more a month, for longer than three months. True (primary) chronic daily headaches aren't caused by another condition. There are short-lasting and long-lasting chronic daily headaches. Long-lasting headaches last more than four hours. They include:
Chronic migraine
Chronic tension-type headache
New daily persistent headache
Hemicrania continua

Hello, I am 23 years old. I have frizzy hair. Recommend some tips for improving my frizzy hair. Sometimes I find it very difficult to manage my hair. Please advise something so that I can apply that.

Hello, I am 16 years old. I am getting hair loss problem. My hair does not grow properly. I am worried about it. It may lead to baldness. Please advise on how to improve hair growth and quality.