@taniya It is important for clinicians to know that PTLD leads to real, quantifiable brain changes and that patients' cognitive complaints may be a direct consequence of these brain changes, rather than a side effect of other symptoms, such as fatigue, for example

The odds of a person with type 1 diabetes achieving target A1c levels and avoiding severe hypoglycemia increase with greater degrees of automation in the technology they're using, new real-world data show. Most notably, the likelihood of experiencing a severe hypoglycemic episode in the prior year was more than double for those taking multiple daily injections (MDI) of insulin without use of a continuous glucose monitor (CGM) compared with those using hybrid closed-loop automated insulin delivery, also known as artificial pancreas systems.

@dhitishree It's quite clear that the mortality currently and acute cardiogenic shock rate is the same as in patients with infarction treated according to current possibilities, so I think it has to be taken seriously

@lalima Weekly physical activity averages were evaluated using the self-reporting Canadian Community Health Survey, which was linked with administrative databases to evaluate the association of physical activity with long-term risk for mortality among stroke survivors compared with controls. Physical activity was measured in metabolic equivalents (METs); meeting minimum physical activity guidelines was defined as 10 MET-hours/week. During the study period, more stroke patients than controls died (24.7% vs 5.7%). However, those who met the physical activity guideline recommendations of 10 MET-hours/week had a lower mortality, both in the stroke survivor group (14.6% vs 33.2%; adjusted hazard ratio, 0.46; 95% CI, 0.29 - 0.73) and among control participants (3.6% vs 7.9%; aHR 0.69; 95% CI, 0.62 - 0.76).

@aparajita Research suggests that plant-based diets reduce the risk for cardiovascular disease, but few studies have examined the effect of these diets on the risk for stroke. Moreover, published research on this question has yielded conflicting results, the researchers note. Two previous investigations showed no association between a vegetarian diet and risk for stroke mortality, but one study found that vegetarian patients were at increased risk for total and hemorrhagic stroke.

@sumon Compared with cancer survivors who sat for less than 4 hours each day, cancer survivors who reported sitting for more than 8 hours a day had nearly twice the risk of dying from any cause and more than twice the risk of dying from cancer. Cancer survivors who sat for more than 8 hours a day, and were inactive or not active enough, had as much as five times the risk of death from any cause or cancer.

Longstanding anxiety around use of epinephrine autoinjectors has prompted research into alternative delivery routes for this life-saving medication. Several companies presented posters on their needle-free epinephrine products at the American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting. Intranasal formulations are under development at ARS Pharmaceuticals (San Diego, California) and Bryn Pharma (Raleigh, North Carolina). And Aquestive Therapeutics (Warren, New Jersey) is working on a sublingual film that delivers epinephrine prodrug when applied under the tongue.

The insula and frontal cortex are involved in the development of anxiety in adults with Parkinson’s disease, according to imaging data from 108 individuals. Anxiety occurs in approximately 31% of Parkinson’s disease patients, but the underlying mechanisms are not well understood, wrote Nacim Betrouni, MD, of the University of Lille, France, and colleagues. Previous research has shown associations between anxiety severity and increased activity in brain areas of emotion processing, based on MRI and positron emission tomography, but electroencephalography (EEG) has not been widely used

Hello, The ongoing COVID-19 pandemic has affected millions of people worldwide and revealed several neurological syndromes related to this infection. One of my friend is suffering from facial palsy after getting covid infection. Please leave your comments on this.

@anushuya As with most questions about Omicron, we don’t yet know for sure—scientists are racing to collect data to see how effective our current vaccines are against this variant. The very preliminary initial data provides some assurances. At least some of the people who have been infected with Omicron in South Africa have been vaccinated, though we don’t yet know which vaccines they received or when they were vaccinated. But the initial data indicates that those vaccinated people have not become severely ill, meaning that current vaccines may still provide strong protection against serious illness. Pfizer and BioNTech announced that preliminary lab studies showed that three vaccine doses—which people who have received a booster have gotten—appeared to provide robust protection against Omicron. The companies said that antibodies found in blood from people who had received just two doses of vaccine appeared to be less protective against Omicron overall but that there were indications that people who had not yet been boosted may still be protected against severe disease.