How phage can be used for clinical application?
There is emergence of applications of bacteriophages in the treatment of localized infections in humans. In the recent years, multidrug-resistant bacteria have become a global threat, and phage therapy may to be used as an alternative to antibiotics or, at least, as a supplementary approach to treatment of some bacterial infections. How phage can be used for clinical application? Please elaborate on this.
@jiniya bacteriophages have been considered to be potential antibacterial therapeutics for the treatment of various infectious diseases in humans. Initially, clinical application of bacteriophages was aimed at the treatment of acute intestinal diseases and skin infections. Later, bacteriophages were applied in surgical practice for treatment of purulent wounds and postoperative infectious complications, and this approach was used in the USSR in the thirties and forties of the twentieth centuryAfter the advent of antibiotics, phage therapy was ceased in most countries and considerably decreased in surgical practice in the USSR. However, the use of bacteriophages in the clinical treatment of infected wounds was not stopped in Eastern Europe and the former SU, as antibiotic treatment of such infections sometimes failed, even in cases of antibiotic-sensitive bacteria. Phage preparations approved for clinical application have been produced in the Russian Federation, Republic of Georgia, and Poland, and a large number of studies on phage therapy have been reported in these countries including investigations published in Russian scientific literature