Micronutrient Supplementation to Prevent, Improve HF?
A new review suggests that micronutrient supplementation — particularly a combination of coenzyme Q10 (CoQ10), zinc, copper, selenium, and iron — might be a potential strategy to improve myocardial function in patients with heart failure (HF) by improving mitochondrial function. Macronutrients, such as fatty acids, lactic acid, and carbohydrates, are the main energy sources for cardiomyocytes and are consumed in large quantities, but micronutrients — including vitamins, minerals, and essential amino acids — are also necessary to convert these macronutrients into energy and are required in very small amounts, which a healthy diet normally produces.
@soumalya Low plasma concentration of several micronutrients, including vitamin D, selenium, zinc, and iron, have been associated with adverse outcomes in HF. Up to 50% of HF patients may be deficient in one or more of these micronutrients, perhaps because patients with HF may have reduced intestinal absorption and increased urinary excretion. A major player in both the development and the worsening of HF is reduction in bioenergetic capacity. Although macronutrients are the main energy sources for cardiomyocytes, small quantities of micronutrients are necessary to convert macronutrients to adenosine triphosphate (ATP).