Heartburn Drug Shows Promise Against COVID-19!
In adults with mild to moderate COVID-19, treatment with a high-dose of famotidine led to early resolution of symptoms and inflammation in a randomized placebo-controlled trial. Cytokine release drives inflammation and poor outcome in patients with COVID-19. In laboratory studies, famotidine reduced type-I interferon release from SARS-CoV-2 infected epithelial cells. Famotidine also improved the COVID-19 outcomes in some retrospective studies and a case series, but evidence from a controlled clinical trial was lacking, until now.
@nilabjo Famotidine is a safe, low- cost and widely available medication with excellent tolerability and minimal known drug-drug interactions that has been taken by millions of patients worldwide. Famotidine is likely to remain a drug used for COVID- 19, either prescribed by physicians or self-administered by patients. Our finding may support this use of famotidine, given that we show that famotidine is well tolerated and that it accelerates the resolution of symptoms and inflammation without compromising immunity.