How to treat acute mountain sickness?
A 19-year-old student who lived at sea level drove to approximately 8000 ft (2440 m) in the Sierra Nevada Mountains to go skiing. After spending a restless night at altitude, he awoke the next morning with a severe headache. During the day, he felt tired, did not have much appetite, and vomited after attempting to eat lunch. By the next morning, however, he felt better and was able to ski with his friends.
@raju Despite a great deal of study, the exact mechanism by which hypoxia causes AMS is still unknown. Hypoxia leads to increased cerebral blood flow, elevated hydrostatic capillary pressure, capillary leak, and, finally, edema. Others have suggested that AMS develops in people who cannot compensate for brain swelling. People with a greater ratio of cerebrospinal fluid (CSF) to brain volume are less likely to develop AMS because the swelling brain is able to displace the CSF. Conversely, those with lesser CSF to brain volume ratio have limited space for compensation of brain swelling and are prone to AMS. The role of fluid retention in the pathogenesis of AMS remains uncertain. Secretion of antidiuretic hormone and atrial natriuretic factor is altered in AMS and may contribute to vasogenic edema. More recently, hypoxia-induced alterations in oxidative stress and free radical metabolism have been implicated in the pathophysiology of AMS