Pharmacology of nonoxynol-9 vaginal (OTC)?

[Pritha]

Nonoxynol-9 vaginal (OTC) is indicated for prevention of pregnancy; when used with a condom (foam or gel) or diaphragm (gel), efficacy is increased. What is the pharmacology and adverse effect?

[Banani]

@pritha Surfactant used as a vaginal spermicide; acts locally during intercourse to immobilize, inactivate, damage, and/or kill sperm.
Adverse effects include burn, itching, rash, or other irritation of vagina or penis.