Depression, MCI Combo Dramatically Accelerates Brain Aging!
Older adults with both depression and mild cognitive impairment (MCI) may have brain biomarkers signifying an increased risk for accelerated brain aging, which could then lead to the development of dementia, new research suggests. The study, which included 80 patients older than 64 years with depression, showed that those who also had MCI vs those with normal cognition had significant differences in the brain activity of 24 proteins involved in the regulation of several pathways, including inflammation, intracellular signaling, and cell survival, as well as a greater risk for cerebrovascular disease.
@sandesh Better understanding of the neurobiology of cognitive impairment in depression can provide new targets for developing more specific treatments, not only for its prevention and treatment but also for its downstream negative outcomes, including the development of dementia and related disorders," she added in a release. Whole-blood samples were taken from all participants and tested for the proteins associated with pathways for cancer, cardiovascular disease, metabolic syndrome, psychiatric disorders, and neurodegenerative disorders.