Antihistamine May Decrease Schizophrenia Symptoms

[Mithila]

The long-acting histamine H2-receptor antagonist famotidine may decrease symptoms of treatment-resistant schizophrenia, new research suggests. A small, randomized controlled trial (RCT) of patients in Finland with this type of disorder showed that those who received a high dose of famotidine for 4 weeks had significantly greater reductions in symptom scores compared with the participants who received matching placebo.

[Ayushi]

@mithila Histamine has received relatively little attention in clinical studies of psychiatric disorders even though it has important functions as a regulator of several key neurotransmitters. The most direct human data on the role of histamine in psychosis shows that patients with schizophrenia have lower histamine H1 receptor levels.