Aortic Stenosis Progression Linked to Higher A1c Levels
In patients with mild or moderate aortic stenosis (AS), higher A1c levels were significantly associated with a faster rate of AS progression. Although the association between diabetes and accelerated AS progression is well-established, no study previously investigated the association between degree of glycemic control and the rate of AS progression. The authors said that their findings further highlight the importance of glycemic control in patients with diabetes and mild to moderate AS. More intensive glycemic control might minimize AS progression in patients with diabetes and mild to moderate AS.
@manideepa The AS progression rate was significantly proportional to A1c level at baseline, with a more rapid rate of progression in those with a higher baseline A1c. In a multivariable logistic regression analysis, mean A1c level at baseline was significantly associated with accelerated AS progression, with an adjusted 27% increased rate of faster AS progression for each 1 percentage point increase in baseline A1c. When the authors analyzed A1c as a categorical variable, an A1c of 7% or higher at baseline significantly linked with an adjusted 52% increased rate of accelerated AS progression compared with people with an A1c of less than 7% at baseline.