SARS-CoV-2 mRNA Vaccine Might Trigger Corneal-Transplant Rejection
Two older women who underwent a Descemet's membrane endothelial keratoplasty (DMEK) transplant and later received a COVID-19 mRNA vaccine have presented with symptoms and signs of endothelial graft rejection, according to a new U.K. report. In one case, the DMEK was recent at the time of vaccination, but in the other it had taken place years earlier. In both cases, one unilateral and the other bilateral, the transplant rejection was treated successfully with topical corticosteroids.
@sudeshna Clinicians and patients should be aware of the potential of corneal graft rejection associated with vaccine administration and may wish to consider vaccination in advance of planned non-urgent keratoplasties. Patients should be counseled on the symptoms and signs that require urgent review to allow early treatment of any confirmed rejection episode.