Sustained Jawline Definition From Hyaluronic Gel, Study Reports
After several promising early phase studies, an injectable hyaluronic gel has been associated with sustained improvements in the appearance of the jaw in patients with poor jawline definition, according to data from what study authors characterized as a "pivotal" randomized multicenter trial. The results were presented during a late-breaking research session at the American Academy of Dermatology 2022 annual meeting in Boston, Massachusetts. The primary outcome, assessed at 6 months, was at least a 1-point improvement in a photonumeric scale used to grade jawline sagging, reported Jeremy Green, MD, Skin Associates of South Florida, Coral Gables. When those randomized to the hyaluronic filler gel VYC-25L (Vycross, Juvéderm) were compared with untreated controls, 68.5% versus 38.4% met the criterion for benefit at 6 months. Importantly, the effect in treated patients was sustained when reevaluated at 12 months. Green reported that the response is generally sustained at the maximum follow-up, now out to 17 months.
@sudeshna In this study, 208 patients with severe (74%) or moderate loss of jawline definition were randomized in a 3:1 ratio to receive the filler or serve as controls. The initially untreated controls received the gel after the primary outcome analysis at 6 months. The hyaluronic gel was injected at five sites along the jawline. The mean age of participants was 58 years. The majority were women, and most were White. Dermatologists blinded to treatment compared photos at 6 months relative to those taken at baseline using the photonumeric grading system of 1 to 5. Change in patient satisfaction at 6 months and again at 12 months relative to baseline was also evaluated. From baseline, when 28.9% of participants reported satisfaction on the Global Aesthetic Improvement Scale (GAIS), rates rose to 89.0% at month 6. There was a decline at month 12, but 79.9% remained satisfied after this period of follow-up.