Early Exposure to Antibiotics Augments Allergy, Eczema Risk
Rates of hayfever and eczema are higher in children exposed to antibiotics in the first 2 years of life than in unexposed children, according to results from a systematic review and meta-analysis. For their meta-analysis, presented here at the European Respiratory Society International Congress 2016, Dr Ahmadizar and her colleagues examined cohort, case–control, and cross-sectional studies published between January 1966 and November 2015. They looked at 21 studies involving 394,517 children with hayfever, 22 studies involving 229,080 children with eczema, and 12 studies involving 64,638 children with both. Overall, early antibiotic exposure was associated with an increased risk for hayfever (odds ratio [OR], 1.23) and for eczema (OR, 1.26). The highest risks for hayfever and for eczema were seen in cross-sectional studies.
@aradhya For both hayfever and eczema, the association was stronger in children treated with two or more courses of antibiotics than in those treated with just one course. The researchers did not have sufficient data to look at the association between each condition and type of antibiotic.