Biomarkers in Young Adults May Predict Origins of Preserved-EF Heart Failure
Two biomarkers linked to endothelial activation, measured in young adulthood, may predict subclinical myocardial changes in middle age that herald later heart failure with preserved ejection fraction (HFpEF), say researchers who conducted an observational study. Elevations in the two inflammatory biomarkers — cellular adhesion molecules E-selectin and ICAM-1 — are considered signs of endothelial activation and markers of existing HFpEF.
@durba The biomarkers E-selectin and ICAM-1 were drawn at year 7 of the study, so the participants were, on average, quite young in their adulthood. And we saw the associations with echocardiographic outcomes as late as 23 years later in the case of E-selectin