Targeting the Microbiota May Help Manage Type 2 Diabetes
An article published in Medicine of Metabolic Diseases looks at the developments in research on the gut microbiota and examines new possibilities for management for people with type 2 diabetes. New bacterial analysis technologies have made it possible to identify all the bacteria present in the gut microbiota of obese and diabetic mice that were treated or that were not treated with prebiotics (fructooligosaccharides) and that received a control diet. More than 100 taxa were found to be affected by the prebiotics, including a new bacterium called Akkermansia muciniphila, which belongs to a new genus of bacteria that live close to the intestinal mucosa.
@khushboo In animal models, levels of A muciniphila, one of the most abundant bacteria of the gut microbiota, were inversely correlated with body weight, adiposity, blood glucose, and intestinal permeability. Administration of A muciniphila to mice receiving a high-fat diet was associated with an increase in the mucus layer and restoration of the expression of tight junction proteins, antimicrobial peptides, and bioactive lipids with anti-inflammatory properties. A muciniphila also was associated with a decrease in obesity, inflammatory parameters, and insulin resistance and an improvement in glucose tolerance.