Gut Microbiome Species Predict Type 2 Diabetes
Six key bacterial species of the gut microbiome have been identified as predictors of the development of type 2 diabetes, according to results from a 15-year follow-up study of more than 5000 people in Finland. The findings are from a prospective study of data on fecal samples from 5572 people in Finland in 2002 in the FINRISK 2002 population cohort. In 2017, the samples were sent for sequencing as follow-up. Of note, the study excluded people with prevalent diabetes at baseline, including those being treated with antidiabetic drugs such as metformin.
@kanish Over a median follow-up of 15.8 years, 432 (7.8%) participants went on to have a diagnosis of type 2 diabetes, and the presence of four species and two clusters at baseline were significantly associated with the development of type 2 diabetes. The four species include Clostridium citroniae (hazard ratio [HR], 1.21; unadjusted P = .02), C. bolteae (HR, 1.20; unadjusted P = .01), Tyzzerella nexilis (HR, 1.17; unadjusted P = .03), and Ruminococcus gnavus (HR, 1.17; P = .04). And the two positively associated clusters mostly consisted of the same species (both HR, 1.18). Importantly, the associations were nearly the same among participants in eastern and western Finland, which are known for having unique genetic as well as lifestyle differences that impact morbidity and mortality.