Positive Findings in Multi-Interventional Dementia Study
Interim results from a multidomain interventional study that has the aim of preventing cognitive impairment and disability by managing vascular and lifestyle risk factors show successful reductions in weight, body mass index (BMI), and low-density lipoprotein (LDL) cholesterol levels in patients at risk for dementia, researchers report. Miia Kivipelto, MD, professor of clinical geriatric epidemiology from the Karolinska Institute in Stockholm, Sweden, is leading the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) trial, working with colleagues from the University of Eastern Finland in Kuopio and the University of Helsinki, Finland. She presented these 1-year results of the FINGER study here at the Alzheimer's Disease International (ADI) 27th International Conference.
@titiksha FINGER has 1,200 participants, aged between 60 and 77 years, drawn from 2 previous population-based noninterventional studies (the Finland Cardiovascular Risk Study [FINRISK] and the National Type 2 Diabetes Prevention Programme in Finland [Fin-D2D]). The participants were divided equally between the intervention and control arms of the study, which is being conducted in 6 centers across Finland. Selection was carried out according to patients' risk of developing dementia, determined on the basis of a dementia risk score and a vascular risk factor profile at midlife. At baseline, mean BMI was 30, and 40% of participants had impaired glucose tolerance. These criteria provided an at-risk population most likely to benefit from the interventions used in the study. Patients were excluded if they already had a clear diagnosis of dementia.