Obesity Leads to Depression via Social and Metabolic Factors
New research provides further evidence that a high body mass index (BMI) leads to depressed mood and poor well-being via social and physical factors. Obesity and depression are "major global health challenges; our findings suggest that reducing obesity will lower depression and improve well-being," co–lead author Jessica O'Loughlin, PhD student, University of Exeter Medical School, Exeter, United Kingdom, told Medscape Medical News.
@debmalya The analysis showed that a genetically determined 1 standard deviation higher BMI (4.6 kg/m2) was associated with higher likelihood of depression (odds ratio [OR]: 1.50; 95% CI: 1.15 – 1.95) and lower well-being (β: -0.15; 95% CI: -0.26 to -0.04). Using genetics to distinguish metabolic and psychosocial effects, the results also indicate that, even in the absence of adverse metabolic effects, "higher adiposity remains causal to depression and lowers wellbeing," the researchers report.