Does early menopause cause dementia?
Earlier menopause appears to be associated with a higher risk of dementia, and earlier onset of dementia. Compared with women who enter menopause around age 50, women who experience very early menopause (before the age of 40 were found to be 35% more likely to develop some type of dementia later in life, according to a large study. Women who entered menopause before age 45 were also 1.3 times more likely to develop dementia before the age of 65. Does early menopause cause dementia?
@baldassare During menopause, estrogen drops women typically enter menopause in their early 50s, many do so earlier. According to the study Women with early menopause may need close monitoring of their cognitive decline in clinical practice. The higher risk for dementia may be due to the decline in estrogen that takes place during menopause. Estrogen can activate glutathione, reduce ApoE4, the most common genetic risk factor in the pathogenesis of dementia, and reduce amyloid plaque deposition in the brain. The build-up of amyloid plaques in the brain is one of the hallmarks of Alzheimer's disease, the most common type of dementia. Thus, it increases the risk of dementia.