Plasma Glucose Surpasses A1c for Flagging Early Dysglycemia
In 15 people with normal A1c levels (< 5.7%; 39 mmol/mol) but at high risk for developing type 2 diabetes both 1-hour interstitial continuous glucose monitoring (CGM) and a 1-hour plasma glucose (PG) measure during an oral glucose tolerance test (OGTT) could identify glycemic variability and dysglycemia, and hence, may be superior to A1c as early indicators of incident dysglycemia. CGM may be a potential alternative to PG as the best way to assess a patient's responses during an OGTT.
@sneha Identifying dysglycemia at an early stage allows for lifestyle intervention to prevent or slow progression to type 2 diabetes. Although A1c is widely used to screen for prediabetes (5.7%-6.4%; 39-46 mmol/mol) and type 2 diabetes (≥ 6.5%, 48 mmol/mol), it is insensitive for identifying the early stages of beta-cell dysfunction. People with incident type 2 diabetes are often diagnosed after significant beta-cell dysfunction has already occurred.