Elevated Serum Phosphate Could be a Risk Factor for Aortic Stenosis, Study Suggests
A new study suggests that increased levels of serum phosphate, but not calcium or vitamin D, could be a significant risk factor for incident aortic stenosis (AS). The findings were published in the European Journal of Preventive Cardiology . Calcific AS is the leading cause of mortality from nonrheumatic valvular disease, yet there is an unmet need for therapies that can slow down or arrest disease progression.
@kankana The population-based study included 296,415 UK Biobank participants who had not been previously diagnosed with valvular heart disease. Phosphate, calcium, and vitamin D levels were determined from serum samples taken at baseline. The calcium-phosphate product value was calculated by multiplying the serum calcium and phosphate levels; 1232 cases of AS were identified from the records over an average follow-up of 8.1 years. In the fully adjusted model, the highest quintile of serum phosphate levels was associated with an increased risk of incident AS (HR 1.56; 95% CI 1.29 to 1.87) compared with the lowest quintile. Every 0.5-unit rise in serum phosphate levels increased the risk of AS by 50% (HR 1.50; 95%CI 1.26 to 1.80). A similar association was seen between serum levels of calcium-phosphate product and AS risk (HR per 0.5-unit increase 1.18, 95% CI 1.10 to 1.26).