Inflammatory Diet Linked to Increased All-Cause Dementia Risk
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A proinflammatory diet, as measured by the dietary inflammatory index (DII), is associated with increased risk of all-cause dementia, although not Alzheimer's disease, according to a new analysis of longitudinal data from the Framingham Heart Study Offspring Cohort.
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@aagami The lack of an association with Alzheimer's disease was a surprise because amyloid-beta prompts microglia and astrocytes to release markers of systemic inflammation, according to Debora Melo van Lent, PhD, who is a postdoctoral fellow at the University of Texas Health San Antonio – Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases. "We expected to see a relationship between higher DII scores and an increased risk for incident Alzheimer's disease," said Melo van Lent, who presented the findings at the 2021 Alzheimer's Association International Conference.