Do NSAIDs Negate Bone Effect of Bisphosphonates?
Nonsteroidal anti-inflammatory drugs (NSAIDs) showed signs of counteracting the effects of bisphosphonate on bone, according to new research. An exploratory post hoc analysis of data from a randomized clinical trial (RCT) found women taking clodronate plus an NSAID saw a 49% adjusted increase in their risk of osteoporotic fractures compared with women on clodronate who weren't using NSAIDs, researchers report in the Journal of Bone and Mineral Research.
@chapal At least one incident of osteoporotic fracture occurred in 440 women during the follow-up period, which was the same for both NSAID users and nonusers (mean, 2.77 years). Hip fractures accounted for 110 of these fractures. Among the placebo group, the rates of osteoporotic and hip fractures did not differ between the groups with (9.5%) or without (9.7%) NSAID use. Among the women treated with clodronate, however, NSAID use was linked to a 49% higher risk of osteoporotic fracture (P=0.019) after adjustment for confounders.