Low LDL Means Higher Hemorrhagic Stroke Risk
More evidence supports the link between low-density lipoprotein (LDL) cholesterol levels and an increased risk of intracerebral hemorrhage (ICH). Results from a large, prospective longitudinal study show individuals with LDL below 70 mg/dL had a 65% increased likelihood of ICH over 9 years. Furthermore, the participants with LDL below 50 mg/dL had 169% greater risk compared with their counterparts who had levels in the 70 to 99 mg/dL range.
@amritangshu The investigators assessed 101,510 participants in the Kailuan study in China. At baseline between June 2006 and October 2007, enrollees completed a standardized questionnaire and underwent physical exams and laboratory testing, including LDL values. Assessments were repeated in 2008, 2010, and 2012. The researchers excluded individuals without full LDL cholesterol results, as well as those diagnosed with stroke, myocardial infarction, or cancer at baseline. Almost 14% of the 96,043 remaining participants had an LDL cholesterol value below 70 mg/dL. During the 9 years of follow-up, 753 participants developed a hemorrhagic stroke. Within this group, 179 participants (24%) had LDL cholesterol below 70 mg/dL before the onset of disease.