Novel Brain Stimulation a Game Changer for Severe Depression?
A new type of neuroscience-informed, magnetic brain stimulation has resulted in remission of treatment-resistant depression in almost 80% of patients enrolled in a randomized sham-controlled trial in findings that support earlier results of an open-label trial. This is really the first time that functional neuroimaging has been utilized as a part of a treatment in psychiatry in a prospective way. This is a rapid-acting neuromodulation treatment for depression and there really isn't one of those yet clinically approved
@rukmini-d Stanford neuromodulation therapy (SNT) — which was previously known as Stanford accelerated intelligent neuromodulation therapy (SAINT) — is a high-dose, resting-state, functional connectivity magnetic resonance imaging–guided intermittent theta-burst stimulation (iTBS) protocol. SNT advances repetitive transcranial magnetic stimulation (rTMS) currently approved by the US Food and Drug Administration by targeting the magnetic pulses according to each patient's neurocircuitry and providing a greater number of pulses at a faster pace. The SNT protocol involves 5 consecutive days with a total of 10 iTBS sessions per day at 1800 pulses per session, with 50-minute intervals between sessions. TMS requires 6 weeks of once-daily sessions and has been only modestly effective in inducing remission, the authors note.