H pylori May Undermine Immunotherapy Response in Gastric Cancer
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I came across an article about that H pylori May Undermine Immunotherapy Response in Gastric Cancer. Need more information. Can someone please share?
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@chirayu The study details are as follows
The study was published on researchsquare.com as a preprint and has not yet been peer reviewed.Key Takeaways
Patients with advanced gastric cancer who have active Helicobacter pylori infections were less likely to respond to anti-PD-1 antibody therapy than H pylori–negative patients.Those with active H pylori infections also demonstrated shorter progression-free survival (PFS) and overall survival (OS).
Why This Matters
Overall, patients with advanced gastric cancer do not respond well to immune checkpoint inhibitors.Prognostic markers are needed to identify those patients who will and those who will not respond.
These findings suggest that active H pylori infection could be one such marker.
Study Design
In this small retrospective study, investigators compared the response of advanced gastric cancer to anti-PD-1 antibodies in 34 patients who had active H pylori infections with that of 43 patients who did not.Of the 77 patients, 43 received nivolumab, 29 received pembrolizumab, and five received camrelizumab/toripalimab/tislelizumab.
Key Results
The H pylori–positive group had an almost threefold greater risk of nonclinical response (odds ratio [OR], 2.91).The H pylori–negative group demonstrated longer median PFS (8.4 vs 2.7 months; hazard ratio [HR], 3.11) and OS (17.5 vs 6.2 months; HR, 2.85).
On multivariate regression, active H pylori infection was independently associated with shorter PFS (HR, 1.90) but not shorter OS (HR, 1.76; 95% CI, 0.99 – 3.12).
Limitations
The study was a small, retrospective investigation.Data on other prognostic factors — PD-L1 positivity, high microsatellite instability, and Epstein-Barr virus infection — were not included in the multivariate regression analysis.