Novel Drug 'Promising' for Concomitant Depression, Insomnia

[Diptangshu]

The novel antidepressant seltorexant (Janssen Pharmaceuticals) may be beneficial for patients with concomitant major depressive disorder (MDD) and sleep disturbance, new research suggests. In a randomized, placebo-controlled, adaptive dose-finding study conducted in more than 200 patients with MDD, those with more severe insomnia at baseline had a greater improvement in depressive symptoms vs those with less severe insomnia.

[Pipi]

@diptangshu As seltorexant is an orexin receptor antagonist, it is related to other medications that are marketed as sleeping pills, so it was important to show that its antidepressant efficacy was actually caused by improved sleep.