Role of Ivermectin in COVID 19??

[Iraban]

Hello, Like every one I am also worried about the COVID 19 pandemic. Each and every day new information is coming up about how to kill the virus or how to get ourselves protected. I came to know that prophylactic Ivermectin administration can prevent us from getting infected. I would like to learn the mechanism behind it. Can anyone leave their opinion or any information?

[Mithila]

@Iraban Reports from in vitro studies suggest that ivermectin acts by inhibiting the host importin alpha/beta-1 nuclear transport proteins, which are part of a key intracellular transport process that viruses hijack to enhance infection by suppressing the host’s antiviral response. In addition, ivermectin docking may interfere with the attachment of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to the human cell membrane. Ivermectin is thought to be a host-directed agent, which may be the basis for its broad-spectrum activity in vitro against the viruses that cause dengue, Zika, HIV, and yellow fever. Despite this in vitro activity, no clinical trials have reported a clinical benefit for ivermectin in patients with these viruses. Some studies of ivermectin have also reported potential anti-inflammatory properties, which have been postulated to be beneficial in people with COVID-19.