Approach consideration in peripheral vascular disease
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What are the approach consideration in the treatment of peripheral vascular disease (PVD)?
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@inika Therapeutic recommendations include single-agent antiplatelet agents for prevention of cardiovascular events in patients with asymptomatic and symptomatic peripheral arterial disease (PAD). These medications should be used in conjunction with efforts to reduce risk factors, including smoking cessation and exercise therapy.
Statins have been linked to improved prognosis in other vasculopathies, including renovascular and cardiovascular events. Although lacking an immediate effect on any vascular process, statins show promise in slowing the progression of atherosclerotic disease systemically.
When conservative measures fail to improve quality of life and function, endovascular procedures are considered. However, the timing and need for revascularization are related to the general primary presentations of claudication, critical limb ischemia, and acute limb ischemia, in which urgent intervention is warranted for critical limb ischemia.
An emerging treatment for peripheral vascular disease (PVD) is the use of growth factor (delivered as genes or proteins) and cell therapy. The delivery of growth factors or cells to the ischemic tissue can locally stimulate the regeneration of the functional vasculature network, reperfuse the ischemic tissue, and salvage the limb.