What is the prevalence of spinal muscle atrophy (SMA) in the US?
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What is the prevalence of spinal muscle atrophy (SMA) in the US?
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@aetana The incidence of SMA is about 1 case in 10,000 live births. The prevalence of persons with the carrier state is 1 in 50. SMA can affect any race or gender.
In North Dakota, the incidence is about 1 case in 6720 (15 per 100,000) live births, the prevalence is 1.5 cases in 10,000, and the prevalence of persons with the Werdnig-Hoffman disease carrier state is 1 in 41. SMA appears to be three to 10 times more common in North Dakota than in other areas.
SMA is the most common degenerative disease of the nervous system in children. After cystic fibrosis, it is the second most common disease inherited in an autosomal recessive pattern that affects children. It is the leading heritable cause of infant mortality