Probiotics Improve Physical Function in COPD
Probiotics improve strength and functional capacity in patients with COPD, based on a randomized, placebo-controlled trial. The improvements stem from decreased gut permeability, which reduces circulating inflammatory cytokines, leading to stabilization of neuromuscular junctions, reported lead author Asima Karim, MBBS, PhD, of the University of Sharjah, United Arab Emirates, and colleagues. "The manipulation of gut bacteria with probiotics may be an attractive therapeutic strategy to strengthen the intestinal barrier," the investigators write in Archives of Gerontology and Geriatrics. "Probiotic supplements reduce the pathological translocation of bacterial metabolites and ameliorate the systemic inflammatory state in multiple diseases."
@anjali-1 In COPD, both intestinal permeability and systemic inflammation have been linked with sarcopenia, suggesting a common, yet unexplored thread, according to Karim and colleagues. "To our knowledge, no previous study has investigated the effects of probiotics on sarcopenia in COPD patients," they write. "However, probiotics are shown to reduce lung inflammation and improve airway remodeling in experimental animal models of COPD. Their trial enrolled 104 men with COPD between 63-73 years of age. Patients were randomly assigned in 1:1 ratio to receive either placebo or a probiotic containing 112 billion live bacteria, including one strain of Streptococcus, three strains of Bifidobacterium, and four strains of Lactobacillus.